Last 5-Year PYQs in Pharmacology for FMGE 2025

When it comes to preparing for FMGE, there is no smarter way to understand exam patterns, identify high-yield topics, and refine your strategy than solving previous years’ questions (PYQs).

Pharmacology is a volatile yet high-scoring subject that requires conceptual understanding, logical connections, and consistent revision. The vast number of drugs, mechanisms, and side effects can be overwhelming—but mastering PYQs can simplify your prep.

What if you had access to the most frequently asked Pharmacology questions from the last five years? That’s exactly what we’ve compiled in this blog.

You’ll find high-yield PYQs with detailed explanations designed to help you grasp tricky drug mechanisms, recall side effects quickly, and apply clinical logic more effectively.

Download FMGE Last 5-Year PYQs – Subject-wise PDFs

FMGE Last 5-Year PYQs Dermatology PDF	FMGE Last 5-Year PYQs Biochemistry PDF	FMGE Last 5-Year PYQs Anatomy PDF
FMGE Last 5-Year PYQs Anesthesia PDF	FMGE Last 5-Year PYQs Pediatrics PDF	FMGE Last 5-Year PYQs Ophthalmology PDF
FMGE Last 5-Year PYQs Microbiology PDF	FMGE Last 5-Year PYQs Medicine PDF	FMGE Last 5-Year PYQs OBG PDF
FMGE Last 5-Year PYQs FMT PDF	FMGE Last 5-Year PYQs ENT PDF	FMGE Last 5-Year PYQs Physiology PDF
FMGE Last 5-Year PYQs Pathology PDF	FMGE Last 5-Year PYQs Pharmacology PDF	FMGE Last 5-Year PYQs PSM PDF
FMGE Last 5-Year PYQs Surgery PDF	FMGE Last 5-Year PYQs Radiology PDF	FMGE Last 5-Year PYQs Orthopaedics PDF
FMGE Last 5-Year PYQs Psychiatry PDF

Let’s get started and take your Pharmacology prep for FMGE 2025 to the next level!

Q1. In paracetamol poisoning, N-acetylcysteine is administered as an antidote. How does it act to prevent toxicity?

1. Inhibits the toxin
2. Removes the toxin
3. Restores glutathione levels
4. Neutralizes liver enzymes

Answer: 3) Restores glutathione levels

Q2. Which antihypertensive drug is contraindicated in pregnancy?

1. Methyldopa
2. Enalapril 
3. Labetalol
4. Nifedipine

Answer 2) Enalapril

Q3. A 35-year-old male presents to the emergency department with complaints of blurred vision, dizziness, and severe headache after ingesting an unknown quantity of homemade alcohol earlier in the day. On examination, he is disoriented. Laboratory tests reveal severe metabolic acidosis with a high anion gap. Which metabolite is primarily responsible for the toxicity in this case?

1. Methanol
2. Formic acid
3. Formaldehyde
4. Acetic acid

 Answer: 2) Formic acid

Q4. Which of the following is the most common side effect induced by cisplatin chemotherapy?

1. GI symptoms
2. Neuropathy
3. Cardiotoxicity
4. Myopathy

 Answer:  1 - GI symptoms

Q5. Which cellular process does Bedaquiline primarily target to exert its therapeutic effect, and how does this mechanism contribute to its antimycobacterial activity?

1. ATP synthesis inhibition
2. Mycolic acid synthesis inhibition
3. Protein inhibition
4. Inhibiting reverse transcriptase enzyme

 Answer:  1 - ATP synthesis inhibition

Q6. Which medication is commonly used as preoperative management for pheochromocytoma to control blood pressure and prevent hypertensive crises?

1. Captopril
2. Propranolol
3. Nifedipine
4. Phenoxybenzamine

Answer: 4 - Phenoxybenzamine

Q7. What is the preferred drug for the treatment of facial nerve palsy?

1. Acyclovir
2. Ceftriaxone
3. Prednisolone
4. Naproxen

 Answer: 3 - Prednisolone

Q8. A 35-year-old female comes to the OPD for well-care visits. The patient is completely well and eats a balanced diet. She never smokes or drinks alcohol and has no significant past medical history. On examination, her vitals are normal. The patient tells the physician that next week she will go on a trip to an island and is worried about motion sickness. Which of the following drugs may be considered first-line therapy for this patient's prophylaxis of motion sickness?

1. Promethazine
2. Ondansetron
3. Metoclopramide
4. Domperidone

Answer: 1 - Promethazine

Q9. Exenatide, a recently introduced medication, is employed for the treatment of diabetes mellitus. The drug's mode of action is characterized by:

1. Inhibition of DPP- 4
2. Release of insulin via acting as agonist of GLP-1 receptors
3. Inhibiting intestinal absorption of carbohydrates
4. Stimulation of PPAR-gamma

Answer: 2-Release of insulin via acting as agonist of GLP-1 receptors

Q10. Which of the following is the compound that prostaglandin, indicated for multiple conditions, is derived from?

1. Stearic acid
2. Arachidonic acid
3. Linoleic acid
4. Linolenic acid

 Answer :2 - Arachidonic acid

Q11. Which drug should not be administered to a pregnant woman? 

1. Erythromycin
2. Amoxicillin
3. Ceftriaxone
4. Streptomycin

  Answer : 4 - Streptomycin

Q12. What is the mechanism of action of methyl dopa?

1. Blockade of beta adrenergic receptors
2. Agonism of beta 2 receptors
3. Agonism of alpha 2 receptors
4. Blockade of alpha 2 receptors

Answer : 3 - Agonism of alpha 2 receptors

Q13. A 60-year-old male came to the emergency department after sustaining a fall. X-ray showed a fractured neck of the femur and was operated on for the same. On postoperative day 2, he experienced a sharp, severe, constant burning pain over his right back. On examination, the lesion is as seen below. The area is tender to light touch, with a rash over the area. What is the most appropriate treatment for this patient?

1. Amitriptyline
2. Topical steroid
3. Valacyclovir
4. Mupirocin

Answer C - Valacyclovir

Q14. Which medication can be administered to reduce the frequency of future headache episodes in a 26-year-old female patient who experiences one-sided pulsating headaches accompanied by nausea, vomiting, and sensitivity to light and finds relief in a dimly lit environment?

1. Propranolol
2. Alprazolam
3. Diazepam
4. Fluoxetine

 Answer A - Propranolol

Q15. A patient took a drug for migraine treatment, following which there was numbness, and his hand appeared as below. What is the possible drug that was taken?

1. Dihydroergotamine
2. Sumatriptan
3. Butorphanol
4. Aspirin

Answer A - Dihydroergotamine

Q16. Which of the following drugs acts by inhibiting the catechol-o-methyl transferase enzyme?

1. Amantidine
2. Rotigotine
3. Tolcapone
4. Selegiline

Answer C - Tolcapone

Q17. Shortest acting corticosteroid is?

1. Dexamethasone
2. Hydrocortisone
3. Triamcinolone
4. Deflazacort
   

Answer:  B - Hydrocortisone

Q18. A 22-year-old woman visits the clinic expressing her desire to conceive. She has a history of epilepsy and is seeking information regarding which antiepileptic medication carries the greatest risk of birth defects and is generally avoided during pregnancy.

1. Valproate
2. Carbamazepine
3. Phenytoin
4. Lamotrigine

Answer:  A - Valproate

Q19. You, being an ardent researcher in the field of vaccine production, are in-charge of  preparing samples to make a vaccine against the new variant of SARS-CoV 2. After getting satisfactory results in preclinical studies, you seek approval to do clinical studies, which requires healthy volunteers. Which of the following phases does this refer to?

1. Phase 1
2. Phase 2
3. Phase 3
4. Phase 4

Answer: A - Phase 1

Q20. Which drug is most likely to cause tremors with prolonged use?

1. Salbutamol
2. Propofol
3. Betaxolol
4. Timolol

Answer:  A - Salbutamol

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