Drugs used for general anesthesia are an important topic in the NEET PG exam because anesthesia is a critical component of many medical procedures. A thorough understanding of the topic is essential for any medical professional.
In the exam, questions related to the pharmacology, mechanism of action, adverse effects, and clinical applications of anesthetic drugs are often asked, making it all the more to study for the NEET PG exam.
All Inhalational agents provide good muscle relaxation but none of them provide analgesia.
All of them can precipitate malignant hyperthermia
Inhalational agents predisposes to this condition, but IV agents are safe in it.
Pharmacogenetic Disease: AD form is expressed.
All halogenated Inhalational Agent
2. Potent inhalational
When a person having gene receives these drugs it gets activated and it stimulates SR which causes massive outflow of calcium inside the cell activating CGMP pathway and this increases the metabolism of our body by 2-3 times.
It presents with
All occur due to hypermetabolism and result in cell lysis, and further cause myoglobinuria, acidosis, renal failure, hyperkalemia.
Discontinue the triggering Agent.
Central Muscle Relaxant.
Stops release of Ca2+.
Side Effects- Respiratory insufficiency and muscle weakness.
Anesthesia safe in Malignant Hyperthermia: TIVA (Total Intravenous Anesthesia)
Propofol: Agent of choice.
MAC: 104, least potent
MAC: 70, more potent than N2O
Blood gas solubility: 0.45
Blood gas solubility: 0.11-0.19 (fastest)
CVS unstable sympathetic stimulation
Not metabolically inert Peripheral neuropathy Megaloblastic anemia Bone marrow depression
Expensive, not in clinical use
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