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New Drugs Approved in 2018

Oct 31, 2018

 

Usually, only 1 question is asked from New Drugs in competitive exams like AIIMS, PGI, NEET. Only JIPMER is one such exam where many questions are asked from this topic. Pharmacology expert, Dr. Gobind Rai Garg advises doing this topic in the end. He says, if you are not particularly preparing for JIPMER exam, try to do this topic of new drugs only if you have already completed the syllabus of Pharmacology. So, don’t waste your time unless you have completed the basics of Pharmacology.

NEW DRUGS APPROVED IN 2018

Below is a comprehensive list of new drugs approved in 2018. The table includes the name of the drug, mechanism, route and indication.
Drug Mechanism Route Indication
Andexanet alpha Bind to Factor Xa inhibitors Intravenous To reverse overdose of rivaroxaban and apixaban
Apalutamide Andreogen receptor antagonist Oral Prostate carcinoma
Avatrombopag Thrombopoietin receptor agonist Oral Thrombocytopenia in patients with chronic liver disease
Baloxavirmarboxil Inhibit viral replication by inhibiting Cap-dependent endonuclease activity of viral polymerase Oral Single dose treatment of Acute uncomplicated influenza
Baricitinib Janus Kinase inhibitor Oral Rheumatoid Arthritis
Bictegravir Integrase inhibitor Oral HIV
Binimetinib MET tyrosine kinase inhibitor Oral BRAF V600E or V600K mutation-positive malignant melanoma
Burosumab Monoclonal antibody against FGF-23 Subcutaneous X-linked hypophosphatemia
Cannabidiol Unknown Oral Lennox Gastaut syndrome Dravet Syndrome
Cemiplimab Monoclonal antibody against Programmed Death receptor (PD-1) Intravenous Squamous cell carcinoma of skin
Cenegermin Recombinant human nerve growth factor Eye drops Neurotrophic keratitis
Dacomitinib EGFR tyrosine kinase inhibitor Oral Non-small cell lung cancer with EGFR exon 19 deletion or exon 21 L858R substitution mutations
Doravirine Non-nucleoside Reverse Transcriptase Inhibitor Oral HIV
Duvelisib Inhibitor of PI-3 kinase gamma and delta Oral Small lymphocytic lymphoma Follicular lymphoma Chronic lymphoid leukemia
Elagolix GnRH antagonist Oral Pain associated with endometriosis
Elapegademase Recombinant Adenosine deaminase enzyme Intramuscular Adenosine Deaminase-Severe Combined Immunodeficiency
Encorafenib BRAF-Kinase Inhibitor Oral BRAF V600E or V600K mutation-positive malignant melanoma
Eravacycline Inhibit protein synthesis like other tetracyclines Intravenous Complicated intra-abdominal infections
Erenumab Monoclonal antibody against CGRP Sc Migraine prophylaxis
Fostamatinib disodium hexahydrate Spleen tyrosine kinase inhibitor Oral ITP
Fremanezumab Monoclonal antibody against CGRP Subcutaneous Migraine prophylaxis
Galcanezumab Monoclonal antibody against CGRP Subcutaneous Migraine prophylaxis
Ibalizumab MAb against CD4 Iv HIV
Inotersen Antisense oligonucleotide against transthyretin mRNA Subcutaneous Polyneuropathy of hereditary transthyretin-mediated amyloidosis
Ivosidenib Isocitrate dehydrogenase 2 (IDH2) inhibitor Oral Acute myeloid leukemia with IDH2 mutation
Lanadelumab Monoclonal antibody against plasma kallikrein Subcutaneous Hereditary Angioneurotic Edema
Lofexidine Alpha 2 agonist Oral To decrease opioid withdrawal symptoms
Lusutrombopag Thrombopoietin receptor agonist Oral Thrombocytopenia in patients with chronic liver disease
Lutetium lu 177 dotatate Peptide receptor radionuclide therapy Intravenous Gastro-entero-pancreatic neuroendocrine tumors
Megalastat Pharmacological chaperone for Alpha galactosidase Oral Fabry’s disease
Mogamulizumab Monoclonal antibody against CCR-4 Intravenous Mycosis fungoides Sezary syndrome
Moxetumomabpasudutox Monoclonal antibody against CD22 conjugated with Pseudomonas exotoxin Intravenous Hairy cell leukemia
Moxidectin Bind to Glutamate and GABA chloride channels Oral Onchocerciasis
Omadacycline Inhibit protein synthesis like other tetracyclines Oral Intravenous Community acquired bacterial pneumonia Acute skin and skin structure infections
Patisiran Small Interfering RNA based therapy against mutant transthyretin Intravenous Polyneuropathy in patients with transthyretin mediated amyloidosis
Pegvailase Substitute of Phenylalanine hydroxylase Sc Phenylketonuria
Plazomicin Inhibit protein synthesis like other aminoglycosides Intravenous Complicated UTI
Sarecycline Inhibit protein synthesis like other tetracyclines Oral Inflammatory lesions of non-nodular moderate to severe acne
Segesterone  + ethinyl estradiol Inhibit ovulation Vaginal ring Contraception (once yearly)
Sodium zirconium cyclosilicate Binds to K and increase fecal excretion oral Hyperkalemia
Stiripentol Increases GABAergic activity Oral Dravet Syndrome
Talazoparib PARP inhibitor Oral breast cancer with a germline BRCA mutation
Tecovirimat Inhibit formation of extracellular viral forms Oral Small pox
Tefenaquine Free radical mediated killing of hypnozooites Oral Single dose radical cure of P. vivax malaria
Tildrakizumab MAb against IL-23 Sc Plaque Psoriasis
Tizacaftor + ivacaftor CFTR  stimulator and potentiator Oral Cystic fibrosis
Tolvaptan Vasopressin V2 receptor antagonist Oral To slow kidney function decline in adult polycystic kidney disease

Here's how you can easily learn the New Drugs approved in 2018

For more such mnemonics on new drugs download the "Pharmacology by Dr. Gobind Rai Garg" app.  For Android- Click Here For iOS - Click Here Good Luck! Keep Following PrepLadder for more updates!!
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