Aug 04, 2023
Henoch-Schonlein purpura is a condition that causes inflammation of the small blood vessels in the skin, joints, bowels, and kidneys. A purplish-red rash (purpura) develops when blood from inflamed blood vessels bleeds into the skin.
The most obvious symptom of this type of vasculitis is a purplish rash, which frequently develops on the lower thighs and buttocks. Aching joints and stomach pain are additional Henoch-Schonlein purpura symptoms. Serious kidney damage is an uncommon occurrence.
Henoch-Schonlein purpura can affect anyone, however, it most commonly affects children under the age of 10. Usually, the issue resolves itself. Generally speaking, medical intervention is necessary if the condition affects the kidneys.
Small blood vessels in the body become inflamed as a result of Henoch-Schonlein purpura, which can lead to bleeding in the skin, abdomen, and kidneys.
There is no known cause for this early inflammation. It can be the result of an unintentional immunological response to particular triggers.
Nearly half of the patients with Henoch-Schonlein purpura had an upper respiratory infection, such as a cold, at its inception. Additional triggers include exposure to cold weather, hepatitis, chickenpox, strep throat, measles, certain medicines, nutrition, and insect bites.
There are four main characteristics of Henoch-Schonlein purpura, and they are as follows:
IgA has a key part in the pathophysiology of Henoch-Schönlein purpura, despite the fact that this is not entirely understood. IgA-antibody immune complexes deposited in the tiny vessels (often capillaries) of the skin, joints, kidneys, and gastrointestinal tract are brought on by antigenic exposure from an illness or treatment.
Prostaglandins and other inflammatory mediators enter the system as a result of this. Complement C3 receptor cells may bind to immune complexes and accumulate in vessel walls, causing an inflammatory response that is over the top.
Gastrointestinal haemorrhage could result from immune complexes that have been deposited in the gut wall. IgA-mediated immune complexes that affect the kidneys can cause mild proliferative glomerulonephritis or extremely severe crescentic glomerulonephritis. Palpable purpura and petechiae are brought on by immune complex deposition in the skin.
Your doctor can diagnose Henoch-Schonlein purpura if you exhibit the characteristic rash, joint discomfort, and digestive system symptoms. If one of these warning signs or symptoms does not exist, your doctor may suggest one or more of the tests listed below.
experimenting in a lab- Henoch-Schonlein purpura cannot be diagnosed with certainty by a single laboratory test, although various tests can assist exclude other diseases and raise the possibility that Henoch-Schonlein is the cause of the patient's symptoms. They might include
Henoch-Schonlein purpura frequently goes away on its own within a month with no long-term detrimental effects. Rest, a lot of water, and over-the-counter medicines can all help with symptoms.
The duration and intensity of joint and gastrointestinal discomfort may be lessened with the aid of prednisone and other corticosteroids. Because these medications can have serious side effects, talk to your doctor about the benefits and dangers of using them.
If a section of the bowel has ruptured or folded back on itself, surgery may be necessary.
Henoch-Schönlein purpura normally has a good prognosis in patients without renal involvement and is a self-limited condition. Most patients finish their recovery in four weeks. Within 4 to 6 months of the first onset, Henoch-Schönlein Purpura returns in about one-third of patients.
The degree of renal involvement determines the long-term morbidity of Henoch-Schönlein purpura. End-stage renal disease (ESRD) and the need for a kidney transplant occur in about 1% of people with Henoch-Schönlein purpura.
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