Feb 23, 2023
Neonatal sepsis is an important topic in Pediatrics for the NEET PG Exam because it is a serious and potentially life-threatening condition that requires early recognition and appropriate management. It is a significant cause of morbidity and mortality in the neonatal period, especially in premature or low-birth-weight infants.
In this blog we’ll cover the associated risk factors, clinical features, diagnosis and treatment of neonatal sepsis. Keep reading.
A clinical syndrome characterized by signs and symptoms suggestive of systemic neonatal infection with or without bacteremia.
NOTE: Meningitis is commonly associated with LOS
Risk Factors:
Nosocomial | Community acquired |
Prematurity | Poor hygiene |
NICU admission | Poor cord care |
Invasive procedures | Bottle feeding |
Mechanical ventilation | Lack of breastfeeding |
Use of stock solutions | Pre lacteal feeds |
Most Common Organism Responsible for Neonatal Sepsis
In India | → | Acinetobacter > klebsiella |
In hospitals in India | → | Acinetobacter > klebsiella |
In hospitals across the world | → | E. coli |
Early onset sepsis (world) | → | Group B- streptococcus |
Overall throughout the world | → | Group B- streptococcus |
Definitive Test (gold standard) → Blood Culture
Screening Test → Sepsis Screen
Sepsis Screen
Components → Any 2 out of 4 → +ve sepsis screen
Supportive Tests:
Treatment:
Sepsis screen | Blood culture | CSF S/O meningitis | Duration of Antibiotics |
- | - | - | 3 days |
+ | - | - | 1 week (7-10 days) |
±+/- | ++/- | -+ | 2 weeks 3 weeks |
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