Solved Numericals In Pharmacology NEET PG 

Q1. 20 grams of Soframycin cream contains: Framycetin Sulfate – 1% w/w, methylparaben -0.08% w/w, propylparaben – 0.04%  w/w. Calculate the amount of framycetin in this preparation in mg?

w/w→means Both drug as well as preparation has same unit

1% framycetin→1g →100g of the preparation 

100g contains 1g framycetin

 20 g contains - 1100×20=0.2g

       = 0.2 × 1000

       = 200mg

Q2. How will you prepare 100ml normal saline from 10ml of 15% saline solution?

Normal saline = 0.9% Nacl solution 

- 0.9 Nacl100 ml of solution 

We have 15g→ 100 ml

In  0.9g  - 10015×0.9=6ml

6ml + 94 ml distilled water

Also read: Pharmacology Treatment for COVID-19

Q3. Calculate the required volume in ml for oral administration from 30 ml cefadroxil suspension containing 250mg/5 ml for a child. The weight of the child is 10kg and he is suffering from tonsillitis . The dose is 40 mg /kg/day orally in 2 divided doses, Not to exceed 2g per 24 hours.

The Dose is 40 × 10 = 400mg/d = 200mg BD.

250 mg 5ml

1mg →5250

200 mg  - 5250200=4ml

Q4. A solution of adrenaline contains adrenaline in a dose of 1 : 10,000. If you want to inject 1mg of adrenaline, how much volume should be injected?

1:10,000 means →1gramof adrenaline is present in 10,000 ml of 

Solution

1g     → 10,000ml

1000mg →10000ml

1mg - 100001000=10ml

Q5. Calculate the required volume in ml for intravenous injection from a vial of 30ml. The vial contains chloroquine base 40mg/ml for a patient weighing 40 kg at a dose of 3 mg/kg body weight suffering from malaria

Total dose to be given is - 3 × 40kg = 120 mg

40 mg present in 1ml

120 mg -140×120=3ml

Q6. A vial contains benzyl penicillin G, 5 lac units per ml after reconstitution. Calculate the required volume in ml for intramuscular injection from this vial for a child weighing 5kg at a dose 20,000 units per kg

 Total amount we need to give is  = 20,000 × 5 kg = 1,00000 units 

We have 5 lac unit per ml

= 1 lac unitPresent   →  in 1 5=0.2ml

Also read: Details Of Enzymatic Receptors

Q7. A plain insulin vial contains 40 units/ml. How much volume should be taken from this vial to set up an infusion in 500 ml normal saline at a rate of 1ml/min to provide the dose of 0.1 unit/kg/hour for a patient of diabetic keto acidosis weighing 60 kg.

We need to give 0.1 × 60 kg = 6 units /hr or 6/60 = 0.1u/min

1ml = 0.1 u

500ml = 500 x 0.1 = 50 units

40 u - 1m

50 u - 1 - 40 ×50=1.2ml

Q8. A vial contains lignocaine 2%. How much volume should be taken from this vial for setting up an infusion in 500ml normal saline at the rate of 1ml/min to provide the dose of lignocaine  0.20 mg/min for a patient of ventricular tachycardia, whose 

Weight is 60 kg?

Iml  =  0.2 mg

We have 500 ml in fusion, so total will be 

500 × 0.2 = 100mg of lignocaine 

- 2g is present in 100ml or

2000 mg   present in   100 ml

- 100 mg -1002000×100=5ml

We will take 5ml from the vial and mix it with 500 ml of normal saline

Q9. A 70kg patient needs to be started on nitroglycerine infusion. the 5ml ampoule contains 5mg/ml NTG. One ampoule is added to normal saline and made a total of 500ml solution. Calculate the rate of infusion if NTG is required at the rate of 10mcg/min (1 microdrip = 60 drops/ml)

25 mg present in 500 ml

1mg present in = 50025

10 mg (10 x 10^-3)  =50025 ×10 × 10-3

= 0.2 ml

1 ml contains 60 drops

0.2 ml contains 60 x 0.2 = 12 drops/min       

Also read: Frequently Asked Question in General Pharmacology

Q10. 5 IU oxytocin is added to 500ml normal saline. The patient weighs 50 kg. calculate the rate of infusion at the dose of 5 mu/min. (1 ml= 16 drops)?

- 5 IU present in 500 ml

- 5 m/unit 5×10-3u-5005×5×10-3

= 0.5 ml/min

- 1 ml contain 16 drops

So 0.5 contain 8 drops 

Q11. You have to give 180 mg of ceftriaxone to a patient in a 2ml syringe that has 10 divisions per ml. The concentration of this drug in vial is 500 mg/5ml. How many divisions should be filled in 2ml of syringe to give 180 mg?

-   500 mg present in 5 ml.

-   1 ml will be present in 5005ml

-    180 ml will be present in 5005×180

= 1.8 ml

The syringe has 10 divisions per ml.

1ml contain - 10 divisions

1.8 ml contain - 10 x 1.8 = 18 divisions

Q12. 1000 mg of a drug was administered to a patient. 200 mg was cleared in 60 minutes. How much of the drug would be left in the body after 3 hours if the excretion of the drug follows zero order kinetics?

- every one hour – 200 mg cleared from the body 

In 3 hour – 200 x 3 = 600 mg cleared 

- The remaining will be 1000 – 600 = 400 mg 

Q13. 200mg drug was administered to a patient. 75mg of that is excreted in 90 minutes. The given drug follows first order kinetics. How much drug will remain after 6 hours?

- here the drug follows first order kinetics .

every 112hr  =75200 eliminated 

= 125200=58   will remain 

After 112hours, the remaining will be – 200 x 5/8

 In 3 hours - 200 x 5858

In 412 hours - 200 x 5858

In 6 hrs - 200 x 585858 = 30.5 mg

Also read: Important One-liners in Pharmacology

Q14. Calculate the half life of a drug ‘X’ if it has vd of 60 liters and clearance of 2.1 L/min

t12=0.7 ×vdCL

= 0.7 ×602.1 L/min=20 min

Q15. Calculate the hepatic clearance of a drug with hepatic blood flow of 1500 ml/min and  hepatic extraction ratio of 0.6?

CLH  = H ER x Blood flow 

= 0.6 x 1500 ml/min

= 900 ml/min

Q16. A female patient weighing 50 kg is having p. viva x malaria in whom tablet chloroquine is given.The target plasma concentration is 20 mg/L. The volume of distribution of chloroquine is 0.6 L/kg. What will be the loading dose of chloroquine in this patient assuming 100 per oral bioavailability?

Loading dose = Vd x target PC

Vd  =  0.6 x 50 = 30 L

LD = 30 x 20 mg/L

= 600 mg

Q17. Calculate the maintenance dose for a drug with 100% oral bioavailability which needs a target concentration of 5 mg/L and clearance of 10 L/hr and dosed four times a day.

 Maintenance dose (MD)= CL x target PC

= 10 L/hr  x 5 mg/L

= 50 mg / hr

In 6 hr   = 50 x 6 = 300 mg. 

Also read: Pharmacology Important Questions for NEET PG/FMGE 2025

Q18. You have started a drug infusion at a rate of 60 mg/hr. The drug has Vd of 50 litres and clearance of 50ml/min. How much will the drug concentration be at steady state?

MD = CL X target PC

PC  =MDCL=60 mh/h50 x 60 ml/h

= 150  mg/ml

= 0.02 mg/ml

= 20 mg/ml

Download the PrepLadder app now and unlock a 24-hour FREE trial of premium high-yield content. Access Video Lectures, digital notes, QBank, and Mock Tests for FREE to start with the Best NEET PG Coaching Online. Elevate your study experience and gear up for success. Start your journey with PrepLadder today!