Last 5-Year PYQs in Physiology for INI-CET
Jul 9, 2025

Physiology is one of the most crucial subjects to conquer in INI-CET. If you can ace the subject, no one can stop you from acing the exam. No matter how overwhelming memorising Physiology concepts can be, the prep can be made smoother if you focus on Previous Years’ Questions.
However, for you to do that, you don’t need to peruse various resources and waste your time. We’ve brought for you the list of high-yield PYQs from the last five years. These will help you identify important patterns, reinforce key concepts, and boost your confidence before the exam.
Let’s dive right in and help you ace the exam.
Download Last 5-Year INI-CET PYQs – Subject-wise PDFs
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Q1. A and B in the graph below represent which of the following ions, in terms of permeability for action potential generation?

- A is Na+, B is K+
- A is Na+, B is Ca2+
- A is K+, B is Ca2+
- A is Ca2+, B is K+
Answer: 1) A is Na+, B is K+
Q2. Vessel A has a length of L and a diameter of D, and vessel B has 2L and 2D. Considering the flow is laminar through both cylinders, the flow through B is how many times as much as the flow through A?

- 4 times
- 8 times
- 16 times
- 32 times
Answer: 2) 8 times
Q3. Transport of iron into enterocytes is done by which of the following proteins:
- Transferrin
- Ferroportin
- Hepcidin
- Divalent metal transporter – 1
Answer: 4) Divalent metal transporter – 1
Q4. What causes the detachment of myosin from actin filaments?
- Attachment of ATP to the myosin head
- Cessation of calcium release from the sarcoplasm
- Conformational change in Troponin T
- Dissociation of ADP and Pi
Answer: 1) Attachment of ATP to the myosin head
Q5. The correct sequence of events during vomiting are?
- Relaxation of lower esophageal sphincter
- Strong contractions in the stomach
- Inspiration against a closed glottis
- Relaxation of the pyloric sphincter
- Relaxation of upper esophageal sphincter
- Reverse peristalsis in the small intestine
- 6,4,2,5,1,3
- 6,4,3,2,1,5
- 4,6,2,1,3,5
- 4,6,2,5,3,1
Answer: 2) 6,4,3,2,1,5
Q6. What is the normal insensible water loss?
- 100 mL/hour
- 150 mL/hour
- 50 mL/hour
- 200 mL/hour
Answer: 3) 50 mL/hour
Q7. The signaling sequence in a type 2 membrane protein with N-terminal facing cytoplasm is located in?
- Inside the membrane
- At the C-terminal
- At the N-terminal
- Both inside the membrane and at C-terminal
Answer: 1) Inside the membrane
Q8. The image shows changes in membrane potential during an action potential. The region marked between 4 to 5 is due to:

- Influx of Na+
- Efflux of Na+
- Influx of K+
- Efflux of K+
Answer: 4) Efflux of K+
Q9. What is the cause of the relaxation of the intestinal segment following the segment containing the food bolus during peristalsis?
- VIP
- Substances P
- Dopamine from adrenergic fibers
- Acetylcholine from myenteric fibers
Answer: 1) VIP
Q10. Which one of the following is not associated with renal auto-regulation?
- Tubuloglomerular feedback
- Myogenic reflex
- Calcium
- Renal sympathetic system fibers
Answer: 4) Renal sympathetic system fibers
Q11. What is the formula used to calculate Stroke Volume (SV) in the context of cardiac physiology?
- SV = Heart Rate (HR) × Ejection Fraction (EF)
- SV = End-Diastolic Volume (EDV) - End-Systolic Volume (ESV)
- SV = Cardiac Output (CO) / Heart Rate (HR)
- SV = Preload × Afterload
Answer: 2) SV = End-Diastolic Volume (EDV) - End-Systolic Volume (ESV)
Q12. Which lobe is affected by a lesion that results in a deficit in hand-eye coordination?
- Parietal lobe
- Frontal lobe
- Temporal lobe
- Occipital lobe
Answer: 1) Parietal lobe
Q13. Which of the following does not cause a right shift of the oxygen-hemoglobin dissociation curve?
- Increased HbF
- Raised 2,3 DPG
- Acidosis
- Increased CO2
Answer: 1) Increased HbF
Q14. Which of the following hormones are secreted from each layer of the structure marked in the image given below?

a. Glomerulosa- Aldosterone
b. Fasciculata- Glucocorticoids
c. Reticulata- Androgens
d. Medulla- Epinephrine
- a & b are correct
- a, b & c are correct
- b & c are correct
- a, b c & d are correct
Answer: 4) a, b c & d are correct
Q15. Which of the following leads to a decrease in GFR?
- Increased RBF
- Increased Glomerular hydrostatic pressure
- Decreased Bowman's oncotic pressure
- Decreased Glomerular oncotic pressure
Answer: 3) Decreased Bowman's oncotic pressure
Q16. Which of the following are properties of ventricular cardiac muscle?
1. All or none law
2. Length tension relationship
3. Long refractory period
4. Can be tetanized
- 1 only
- 2 only
- 1 and 2
- 1,2,3
Answer: 4) 1,2,3
Q17. Spinal nucleus of the trigeminal is associated with which sensation?
- Vibration
- Conscious proprioception
- Pain
- Two point discrimination
Answer: 3. Pain
Q18. Which hormones possess receptors within the cell?
- Thyroxine
- Epinephrine
- Glucagon
- Parathormone
Answer: 1. Thyroxine
Q19. Arrange the following in the sequence in which they occur, after the 'p wave' in ECG:
A- 'a' wave
B- 1st heart sound
C- Rapid filling of ventricles
D- 't' wave
- ABCD
- ABDC
- CABD
- ACBD
Answer: 2. ABDC
Q20. Which of the following factors is not necessary for determining creatinine clearance?
- Urine creatinine
- Serum creatinine
- Urine flow per unit time
- The volume of serum passing through the kidney in 24 hours
Answer: 4) The volume of serum passing through the kidney in 24 hours
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