Last 5-Year PYQs in Physiology for INI-CET

Physiology is one of the most crucial subjects to conquer in INI-CET. If you can ace the subject, no one can stop you from acing the exam. No matter how overwhelming memorising Physiology concepts can be, the prep can be made smoother if you focus on Previous Years’ Questions. 

However, for you to do that, you don’t need to peruse various resources and waste your time. We’ve brought for you the list of high-yield PYQs from the last five years. These will help you identify important patterns, reinforce key concepts, and boost your confidence before the exam. 
Let’s dive right in and help you ace the exam.

Q1. A and B in the graph below represent which of the following ions, in terms of permeability for action potential generation? 

1.  A is Na+, B is K+
2.  A is Na+, B is Ca2+
3. A is K+, B is Ca2+
4. A is Ca2+, B is K+

Answer: 1) A is Na+, B is K+

Q2. Vessel A has a length of L and a diameter of D, and vessel B has 2L and 2D. Considering the flow is laminar through both cylinders, the flow through B is how many times as much as the flow through A?

1. 4 times
2.  8 times
3.  16 times
4. 32 times

Answer: 2) 8 times

Q3. Transport of iron into enterocytes is done by which of the following proteins:

1. Transferrin
2. Ferroportin
3.  Hepcidin
4.  Divalent metal transporter – 1

 Answer: 4) Divalent metal transporter – 1

Q4. What causes the detachment of myosin from actin filaments? 

1. Attachment of ATP to the myosin head
2. Cessation of calcium release from the sarcoplasm
3. Conformational change in Troponin T
4. Dissociation of ADP and Pi

Answer: 1) Attachment of ATP to the myosin head

Q5. The correct sequence of events during vomiting are? 

1. Relaxation of lower esophageal sphincter 
2. Strong contractions in the stomach 
3. Inspiration against a closed glottis 
4. Relaxation of the pyloric sphincter 
5. Relaxation of upper esophageal sphincter 
6. Reverse peristalsis in the small intestine

1. 6,4,2,5,1,3
2. 6,4,3,2,1,5
3. 4,6,2,1,3,5
4.  4,6,2,5,3,1

Answer: 2) 6,4,3,2,1,5

Q6. What is the normal insensible water loss? 

1. 100 mL/hour
2.  150 mL/hour
3.  50 mL/hour
4.  200 mL/hour

Answer: 3) 50 mL/hour

Q7. The signaling sequence in a type 2 membrane protein with N-terminal facing cytoplasm is located in?

1.  Inside the membrane
2.  At the C-terminal
3.  At the N-terminal
4. Both inside the membrane and at C-terminal

Answer: 1) Inside the membrane

Q8. The image shows changes in membrane potential during an action potential. The region marked between 4 to 5 is due to:

1. Influx of Na+
2. Efflux of Na+
3.  Influx of K+
4.  Efflux of K+

Answer: 4) Efflux of K+

Q9. What is the cause of the relaxation of the intestinal segment following the segment containing the food bolus during peristalsis?

1. VIP
2. Substances P
3. Dopamine from adrenergic fibers
4.  Acetylcholine from myenteric fibers

Answer: 1) VIP

Q10. Which one of the following is not associated with renal auto-regulation?

1. Tubuloglomerular feedback
2. Myogenic reflex
3.  Calcium
4.  Renal sympathetic system fibers

 Answer: 4) Renal sympathetic system fibers

Q11. What is the formula used to calculate Stroke Volume (SV) in the context of cardiac physiology?

1. SV = Heart Rate (HR) × Ejection Fraction (EF)
2.  SV = End-Diastolic Volume (EDV) - End-Systolic Volume (ESV)
3.  SV = Cardiac Output (CO) / Heart Rate (HR)
4.  SV = Preload × Afterload

  Answer: 2)  SV = End-Diastolic Volume (EDV) - End-Systolic Volume (ESV)

Q12. Which lobe is affected by a lesion that results in a deficit in hand-eye coordination?

1.  Parietal lobe
2. Frontal lobe
3.  Temporal lobe
4.  Occipital lobe

Answer: 1) Parietal lobe

Q13. Which of the following does not cause a right shift of the oxygen-hemoglobin dissociation curve?

1. Increased HbF
2. Raised 2,3 DPG
3. Acidosis
4. Increased CO2

Answer: 1) Increased HbF

Q14. Which of the following hormones are secreted from each layer of the structure marked in the image given below?

a. Glomerulosa- Aldosterone

b. Fasciculata- Glucocorticoids

c. Reticulata- Androgens

d. Medulla- Epinephrine

1. a & b are correct
2. a, b & c are correct
3. b & c are correct
4. a, b c & d are correct

 Answer: 4) a, b c & d are correct

Q15. Which of the following leads to a decrease in GFR?

1. Increased RBF
2.  Increased Glomerular hydrostatic pressure
3.  Decreased Bowman's oncotic pressure
4.  Decreased Glomerular oncotic pressure

 Answer: 3) Decreased Bowman's oncotic pressure

Q16. Which of the following are properties of ventricular cardiac muscle?

1. All or none law

2. Length tension relationship

3. Long refractory period

4. Can be tetanized

1. 1 only 
2. 2 only
3. 1 and 2
4. 1,2,3

 Answer: 4) 1,2,3

Q17. Spinal nucleus of the trigeminal is associated with which sensation?

1. Vibration
2. Conscious proprioception
3. Pain
4. Two point discrimination

 Answer: 3. Pain

Q18. Which hormones possess receptors within the cell?

1. Thyroxine
2.  Epinephrine
3.  Glucagon
4.  Parathormone

 Answer: 1. Thyroxine

Q19. Arrange the following in the sequence in which they occur, after the 'p wave' in ECG:

A- 'a' wave

B- 1st heart sound

C- Rapid filling of ventricles

D- 't' wave

1. ABCD
2.  ABDC
3. CABD
4. ACBD

 Answer: 2. ABDC

Q20. Which of the following factors is not necessary for determining creatinine clearance?

1. Urine creatinine
2. Serum creatinine
3. Urine flow per unit time
4. The volume of serum passing through the kidney in 24 hours

Answer: 4) The volume of serum passing through the kidney in 24 hours

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