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Must know ‘New Drugs’ for AIIMS-PG by Dr. Gobind Rai Garg

Jun 05, 2020

Pharmacology expert, Dr. Gobind Rai Garg has come up with a list of important 'New Drugs'. This list has been compiled keeping in mind the upcoming AIIMS-PG exam. After going through this blog, you'll be well versed to answer any question related to this topic in the exam.

IMPORTANT DRUGS FOR AIIMS-PG

The table includes the name of the drug, mechanism, route, and indication.
Drug Mechanism Route Indication
Andexanet alpha Bind to Factor Xa inhibitors Intravenous To reverse overdose of rivaroxaban and apixaban
Brexanolone GABA-A modulator Intravenous Post partum depression
Baloxavirmarboxil Inhibit viral replication by inhibiting Cap-dependent endonuclease activity of viral polymerase Oral Single dose treatment of Acute uncomplicated influenza
Elagolix GnRH antagonist Oral Pain associated with endometriosis
Esketamine Non-competitive NMDA antagonist Intranasal Treatment resistant depression
Ibalizumab MAb against CD4 Intravenous HIV
Pretomanid Inhibit mycolic acid synthesis Oral For XDR and MDR TB (in combination with bedaquiline and linezolid)
Pitolisant H3 antagonist/inverse agonist Oral Narcolepsy
Tenapanor Sodium hydrogen exchanger-3 (NHE-3) inhibitor Oral IBS with constipation
Tafenoquine Free radical mediated killing of hypnozoites Oral Single dose radical cure of P. vivax malaria
Lemborexant Dual Orexin Antagonist (DORA)- binds to both the orexin receptors OX1R and OX2R Oral Insomnia
Remdesivir Remdesivir triphosphate inhibits viral RNA dependent RNA polymerase Intravenous Coronavirus disease 2019 (COVID-19)
Ubrogepant CGRP receptor antagonist Oral Acute treatment of migraine with or without aura
Rimegepant CGRP receptor antagonist Oral Acute treatment of migraine with or without aura
Lasmiditan 5HT1F agonist Oral Acute treatment of migraine with or without aura
Erenumab Monoclonal antibody against CGRP receptor SC Migraine prophylaxis
Galcanezumab Monoclonal antibody against CGRP receptor SC Migraine prophylaxis
Fremanezumab Binds to CGRP ligand blocking its binding to CGRP receptor. SC Migraine prophylaxis
Eptinezumab Binds to CGRP ligand blocking its binding to CGRP receptor. Intravenous Migraine prophylaxis
Romosozumab MAB against sclerostin SC Osteoporosis in postmenopausal women at high risk of fracture

 To enhance your understanding, watch the video on Must Know 'New Drugs' by Dr. Gobind Rai Garg: 

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