Blistering disorders of the Skin - NEET PG Dermatology
Apr 10, 2023
Blistering disorders are a group of skin conditions characterized by the formation of blisters, which can be a presenting feature of a wide range of dermatological diseases. These conditions include autoimmune blistering diseases, infectious disorders, drug reactions, and inherited disorders. Understanding the clinical presentation, diagnostic criteria, and management of blistering disorders is essential for dermatologists to diagnose and manage these conditions accurately.
Acantholysis, dyskeratosis with corps ronds, corps grains
Acantholysis, dyskeratosis with dilapidated brick wall appearance
ERYTHEMA MULTIFORME AND EPIDERMAL NECROSIS
Feature
Erythema Multiforme
Epidermal Necrosis
Cause
Viral infection > Drugs
Drugs
Lesion
Target lesions/Iris lesion/ Bull’s eye lesions
Targetoid lesions Epidermal separation as per body surface area
<10% - Steven Johnson syndrome
10 – 30% (overlap syndrome)
> 30% - TEN
Nikolsky sign
Absent
Present
Mucosal involvement
Absent
present
Hemorrhagic crusting (SJS)
Epidermal separation (TEN)
TEN
Toxic Epidermal Necrolysis
Sheet like epidermal separation
Poor prognosis
Previous Year Questions
Q. Patient presents with oral lesions along with flaccid blisters on scalp, face, trunk and extremities, as shown in the image. Diagnosis? (AIIMS NOV 2019)
Pemphigus vulgaris
Pemphigus foliaceous
Dermatitis herpetiformis
Bullous pemphigoid
Q. Sub epidermal blisters with neutrophils, treatment of choice? (INICET Nov 2020)
Rituximab
Dapsone
Cyclosporine
Azathioprine
Q. A 10-year-old child comes with erosions and blisters on trauma prone areas. There is a history of death of a sibling after 10 days with similar illness. The most probable diagnosis is? (AIIMS JUNE 2020)
Epidermolysis bullosa
Pemphigus
Congenital syphilis
Chronic bullous disease of childhood
Q. Erythema multiforme is seen in? (NEET PG 2019)
Celiac disease
ITP
Antimalarials
Leukemia
Q. Arrange superficial to deep blister disease? (AIIMS MAY 2019)
Pemphigus vulgaris
Linear IgA
Bullous pemphigoid
Epi. Dystrophica
Ans - A>C>B>D
Q. A patient with known case of T.B has been taking multiple medications and now he has presented with the given image, what is the most appropriate diagnosis? (FMGE dec 2020)
Fixed drug eruption
TEN
SJS
Scrofuloderma
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