Nov 02, 2019
After sharing the complete list of New Drugs approved by the FDA in 2019, we have now up with a segregated list of important drugs. This list has been compiled by
Dr. Gobind Rai Garg keeping in mind the upcoming AIIMS Nov exam.
The table includes the name of the drug, mechanism, route and indication.
Drug | Mechanism | Route | Indication |
Afamelanotide | Melanocortin 1 receptor agonist | Subcutaneous | Phototoxicity in patients with erythropoietic protoporphyria |
Andexanet alpha | Bind to Factor Xa inhibitors | Intravenous | To reverse overdose of rivaroxaban and apixaban |
Apalutamide Darolutamide | Androgen receptor antagonist | Oral | Prostate carcinoma |
Avatrombopag Lusutrombopag | Thrombopoietin receptor agonist | Oral | Thrombocytopenia in patients with chronic liver disease |
Baloxavir marboxil | Inhibit viral replication by inhibiting Cap-dependent endonuclease activity of viral polymerase | Oral | Single dose treatment of Acute uncomplicated influenza |
Baricitinib | Janus Kinase inhibitor | Oral | Rheumatoid Arthritis |
Bremelanotide | Melanocortin receptor agonist | subcutaneous | Hypoactive sexual desire disorder in females |
Brexanolone | GABA-A modulator | Intravenous | Post partum depression |
Caplacizumab | vWF-directed antibody fragment | IV/SC | Thrombotic Thrombocytopenic Purpura |
Elagolix
| GnRH antagonist | Oral | Pain associated with endometriosis |
Erenumab Fremanezumab Galcanezumab | Monoclonal antibody against CGRP | SC | Migraine prophylaxis |
Esketamine | Non-competitive NMDA antagonist | Intranasal | Treatment resistant depression |
Ibalizumab | MAb against CD4 | IV | HIV |
Inotersen | Antisense oligonucleotide against transthyretin mRNA | Subcutaneous | Polyneuropathy of hereditary transthyretin-mediated amyloidosis |
Istradefylline | Adenosine A2 receptor antagonist | Oral | Off episode in Parkinsonism |
Lasmiditan | 5HT1F agonist | Oral | Acute severe migraine |
Lofexidine | Alpha 2 agonist | Oral | To decrease opioid withdrawal symptoms |
Megalastat
| Pharmacological chaperone for Alpha galactosidase | Oral | Fabry’s disease |
Moxidectin
| Bind to Glutamate and GABA chloride channels | Oral | Onchocerciasis |
Netarsudil + Latanoprost | Netarsudil: Rho kinase inhibitor Latanoprost: PGF2 apha | Topical | Open angle glaucoma |
Patisiran
| Small Interfering RNA based therapy against mutant transthyretin | Intravenous | Polyneuropathy in patients with transthyretin mediated amyloidosis |
Pitolisant | H3 antagonist/inverse agonist | Oral | Narcolepsy |
Pretomanid | Inhibit mycolic acid synthesis | Oral | For XDR and MDR TB (in combination with bedaquiline and linezolide) |
Ravulizumab | C5 Complement inhibitor | Intravenous | Paroxysomal Nocturnal Hemoglobinuria |
Romosozumab | MAb against sclerostin | Subcutaneous | Post-menopausal osteoporosis |
Selinexor | Selective inhibitor of nuclear export | Oral | Multiple myeloma Diffuse large B cell lymphoma |
Semaglutide | GLP-1 agonist | Oral | Type 2 diabetes mellitus |
Solriamfetol | DA and NA reuptake inhibitor | Oral | For excessive day time sleepiness in Obstructive sleep apnea and Narcolepsy |
Stiripentol
| Increases GABAergic activity | Oral | Dravet Syndrome |
Tafenoquine | Free radical mediated killing of hypnozooites | Oral | Single dose radical cure of P. vivax malaria |
Tecovirimat
| Inhibit formation of extracellular viral forms | Oral | Small pox |
Tenapanor | NHE-3 inhibitor | Oral | IBS with constipation |
Tolvaptan | Vasopressin V2 receptor antagonist | Oral | To slow kidney function decline in adult polycystic kidney disease |
We hope this list will surely prove helpful to you for the upcoming AIIMS exam.
Dermatology, Psychiatry, Anesthesia and Radiology are the minor subjects of Prof 4 that, if prepared effectively, can boost the exam score. To help students prepare f
PrepLadder always strives to enrich your learning experience with best-in-class preparation resources.
Continuing with this legacy of providing our student
One simply cannot underestimate the significance of a reliable and competent educator when it comes to preparing for one India’s most challenging and competitive exam