Endometrial Carcinoma (Endometrial Hyperplasia's, Staging Of Ca Endometrium)
Feb 22, 2023
Endometrial carcinoma is the most common gynecologic malignancy and is responsible for a significant number of cancer-related deaths in women worldwide.
Early detection of endometrial carcinoma is crucial for effective treatment and improved outcomes. NEET PG exam tests a candidate's knowledge of the different diagnostic modalities and management options available for this condition.
Anovulatory conditions → PCOD: persistent high Estrogen
Obesity: Fats (1.5-2.5 times more likely)
Corpus cancer syndrome (Corpus= uterine body)
DM – HTN – Obesity
Abnormal liver function tests: altered estrogen metabolism
LYNCH II: HNPCC (Hereditary Non-Polyposis Colon Cancer): 40% association with Ca endometrium
Familial predisposition
1st degree female relatives can have either of these (even 2nd degree are predisposed)
Ca Breast
Ca Endometrium
Ca Ovary
Nulliparous woman: no break from Estrogen exposure. Each pregnancy gives around a 2 year break from menstruation. Thus it is not a common Indian cancer
Important Information
Excess estrogen: 80% of Ca endometrium: Type 1
No association with E excess: 20% of Ca Endometrium: Type 2
Previous year question
Question: A patient of carcinoma breast on tamoxifen is at a high risk of which of the following? (AIIMS 2020)
1st line Mx of recurrence → High Progesterone [200-250 mg/day]
Important information
Most common cause of postmenopausal bleeding in India: Ca Cervix
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