Last 5-Year PYQs in Pathology for INI-CET

Pathology plays a pivotal role in bridging basic sciences with clinical understanding in INI-CET. It's concept-heavy and frequently tested, making it a must-master subject for success.

To make the most of your revision time, focusing on Previous Years’ Questions is key. These questions reveal examiner patterns and highlight the most test-worthy concepts.

To save your time and effort, we’ve put together a refined set of high-yield Pathology PYQs from the last five years to help you revise more efficiently and confidently.

Download Last 5-Year INI-CET PYQs – Subject-wise PDFs

Q1. Match the following cell types with their associated malignancy:

1. 1-b, 2-a, 3-d, 4-c
2. 1-a, 2-d, 3-c, 4-b
3.  1-b, 2-c, 3-a, 4-c
4.  1-a, 2-b, 3-d, 4-c

Answer: A) 1-b, 2-a, 3-d, 4-c

Q2. A 35-year-old woman presents with fatigue. Investigations reveal the following: Hemoglobin (Hb): 5 gm%, low mean corpuscular haemoglobin (MCH), and low mean corpuscular volume (MCV). The peripheral smear shows microcytic hypochromic red blood cells. What is the most likely diagnosis?

1. Megaloblastic anaemia
2. Iron deficiency anaemia
3. Thalassemia major
4. Essential thrombocytosis

Answer: 2) Iron deficiency anaemia

Q3. The following image shows an instrument used to estimate haemoglobin levels. What does it measure?

1. Alkaline hematin
2. Acid hematin
3. Oxyhemoglobin
4. Deoxyhemoglobin

 Answer: 2) Acid hematin

Q4. Which of the following methods is iron in tissues stained?

1. Masson’s trichrome
2. Prussian blue
3. PAS
4. Fite-Faraco

 Answer: 2) Prussian blue 

Q5. A woman presents with nodular lesions, 4-6 mm in size, on the inner thighs and peri-anal region. The lesions appear pale, and histopathological examination reveals multiple intracytoplasmic inclusion bodies consistent with Henderson-Patterson bodies. What is the most likely diagnosis?

1. Trichodysplasia spinulosa
2. Condyloma acuminata
3. Molluscum contagiosum
4. Donovanosis

 Answer: 3) Molluscum contagiosum 

Q6. Which of the following is not likely to be seen in a patient with paroxysmal nocturnal hemoglobinuria (PNH)?

1. Aplastic anemia
2. Leukaemia
3. Thrombosis
4. Hemolysis

Answer: 2) Leukemia

Q7. In cystic fibrosis, which of the following structures is affected in the pancreas?

1. A
2. B
3. C
4.  D

 Answer: 2) B

Q8. The human papillomavirus inactivates the Rb gene by which of the following proteins?

1.  E6
2. E7 
3. L1
4. L2

 Answer: 2) E7

Q9. Which of the following oil red O stains is used?

1. Formalin fixation
2.  Frozen section
3.  Alcohol fixation
4.  Glutaraldehyde fixation

  Answer: 2) Frozen section

Q10. An electron microscopic picture of a cut section of a nerve fibre is given. Identify the area that will be affected by the most common variant of Guillain-Barre syndrome.

1. 1
2.  2
3.  3
4.  4

  Answer: 2) 2

Q11. All of the following are immunohistochemical markers for GIST, except?

1.  PDGFR Beta
2.  SDH
3.  KIT
4.  NRG-1

Answer: 4) NRG-1

Q12. Which of the following is a new intranuclear immunohistochemistry marker for neuroendocrine tumors?

1.  Synaptophysin
2.  Chromogranin
3.  INSM
4.  NCAM1/ CD56

 Answer: 2 ) INSM

Q13. Which of the following features does not distinguish between necrosis and apoptosis?

1. Enzymatic degradation
2. Association with underlying pathology
3. Lipid change
4. Intact membrane

 Answer: 2) Association with underlying pathology

Q14. Which of the following is not a feature of G6PD deficiency?

1. Males and females are equally affected
2. Oxidative stress
3. Absence of NADPH
4. Presence of Heinz's bodies

Answer: 1) Males and females are equally affected

Q15. Which connective tissue disorder is not associated with aneurysm formation?

1. Marfan syndrome
2. Scurvy
3. Atherosclerosis
4. Ehler-Danlos syndrome

Answer: C) Atherosclerosis

Q16. Match the following blood products with their shelf lives.

1. 1-A, 2-C, 3D, 4-B
2. 1-B, 2-D, 3-A, 4-C
3.  1-C, 2-A, 3-B, 4-D
4.  1-B, 2-C, 3-A, 4-D

 Answer 4 ) 1-B, 2-C, 3-A, 4-D

Q17. The absence of the structure will be present in all except:

1. Pernicious anemia
2. Autoimmune Metaplastic Atrophic Gastritis
3. Vitamin B12 Deficiency
4. Zollinger-Ellison syndrome

 Answer: 4) Zollinger-Ellison syndrome

Q18. The cells lining the isthmus of gastric pits are:

1. Chief cells
2. Stem cells
3. Parietal cells
4. Mucous cells

  Answer: 2) Stem cells

Q19. Which of the following is true about celiac disease?

1. Most common cause of malnutrition in developing countries
2. Can be diagnosed with CECT
3. Improves with food rich in carbohydrates
4. Increased risk of GI lymphoma

 Answer: 4) Increased risk of GI lymphoma

Q20. Which of the following statements regarding Peutz-Jeghers syndrome is correct?

1. An arborizing pattern of smooth muscle
2. Loss of heterozygosity in STK11 gene
3. Multiple GI polyps
4. Autosomal recessive inheritance
5. Congenital hypertrophy of retinal pigmental epithelium is seen

1. 2, 4, 5
2. 1, 2, 3
3.  1, 3, 4
4.  2, 3, 5

Answer: 2) 1, 2, 3

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