Oct 09, 2023
Von Willebrand disease is a chronic bleeding disorder that prevents your blood from clotting properly. Von Willebrand factor malfunction or low levels of the protein, which promotes blood clotting, are signs of the disorder.
The majority of people who have the illness are born with it after either one or both of their parents passed it on to them. Warning signs, such as a lot of bleeding after a dental procedure, may take years to appear.
Von Willebrand's disease has no known cure. The majority of people with this illness may, however, lead active lives with therapy and self-care.
Von Willebrand factor is a blood clotting protein that is controlled by a defective gene that is frequently inherited.
If you have low quantities of this protein, if it isn't working as it should, small blood cells called platelets are unable to adhere to one another properly or naturally bind to the blood vessel walls once an injury has occurred. This interferes with the coagulation process and occasionally leads to uncontrollable bleeding.
A huge number of people are affected by von Willebrand disease in addition to having low amounts of factor VIII, another protein that promotes clotting.
Another inherited clotting disorder involving factor VIII is haemophilia. But unlike haemophilia, which mostly affects men, von Willebrand disease affects both sexes equally and is often milder.
Very rarely, people who did not inherit a defective gene from their parents can eventually get von Willebrand disease. This acquired von Willebrand syndrome is assumed to be caused by an underlying medical condition.
Many people might not know they have von Willebrand disease since it has little or no symptoms. The most frequent symptom of the illness is unusual bleeding.
There are three main types of the illness. Each person's level of bleeding varies depending on the nature and seriousness of the disease.
If you have von Willebrand disease, you might experience:
Here are some examples of menstruation signs and symptoms:
The major risk factor is having a family history of von Willebrand disease. Parents pass on the defective gene to their offspring. Rarely can generations skip the sickness.
The disorder, which is an "autosomal dominant inherited" one, often requires a defective gene from just one parent to cause symptoms. If you carry the gene for von Willebrand disease, you have a 50% chance of passing it on to your children.
The most severe form of the condition is "autosomal recessive," which requires that both of your parents pass a defective gene on to you.
It can be difficult to identify mild forms of von Willebrand disease because bleeding happens frequently and normally doesn't indicate a disease in most people. If your doctor suspects you have a bleeding problem, they could recommend a haematologist.
A thorough physical examination, a review of your medical history, a look for bruises or other signs of recent bleeding, and a von Willebrand disease test are all likely to be performed by your doctor.
Your physician will likely also advise the blood tests listed below:
The same person's test results may change over time due to conditions like stress, exercise, infection, pregnancy, and medication. So you might have to run some tests again.
Your doctor could advise testing for family members to find out if von Willebrand disease runs in your family if you have it.
Although there is no treatment for von Willebrand disease, therapy can help stop or avoid bleeding episodes. Your medical care is dependent upon:
Your doctor might suggest one or more of the following therapies if you want to strengthen blood clots, raise your von Willebrand factor, or lessen excessive monthly bleeding:
If you would like to start a family and von Willebrand's disease runs in your family, you might want to think about genetic counselling. If you carry the gene for von Willebrand disease, you can still pass it on to your children even if you don't exhibit any symptoms.
Rarely, von Willebrand disease can cause uncontrollable, life-threatening bleeding. additionally, adverse symptoms of von Willebrand disease include:
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