Most Important Medicine Topics for NEET PG 2026: High-Yield Guide

A 52-year-old man who has diabetes comes to the emergency room with chest pain that radiates to his left arm. The test that checks his heart rhythm shows some problems in a part of his heart. His troponin levels are going up. We have to act; we only have 90 minutes to save the heart muscle. Do we know how quickly we need to get the blocked artery open? What is the best way to get the blood flowing to his heart again? What medicines should we give him to stop his blood from clotting? This is the kind of thinking that the NEET PG 2026 test will ask for. We have to think about all these things when we are treating a patient. We will see this kind of question a lot in the Medicine part of the test.

QUICK ANSWER

The National Eligibility Cum Entrance Test for Post Graduate or NEET PG has a lot of questions about Medicine. In fact Medicine questions are an important part of the NEET PG. This means that Medicine carries a lot of weight in the PG. There are 200 questions in the PG, and about 40 to 45 of them are about Medicine.

Some areas of Medicine are very important for the PG. These areas include the heart, which is called cardiology. We need to know about things like arrhythmias and heart failure. What happens when someone has a heart attack? We also need to know about the brain, which is called neurology. This includes things like what to do when someone has a stroke and how to help people with epilepsy.

NEET PG RELEVANCE

Medicine dominates NEET PG with 20-22% of total questions. Based on NEET PG 2025 recall analysis, examiners heavily tested cardiology emergencies, acid-base interpretation, and endocrine disorders. Recent papers emphasize clinical vignettes requiring integration of labs, imaging, and treatment protocols — rote memorization alone won't suffice.

What Makes Medicine the King Subject in NEET PG?

Medicine is really important for the NEET PG exam. It is the thing that will decide your rank. There are 45 questions from General Medicine, which includes Dermatology, Venereology, and Psychiatry. These Medicine questions can make a difference in your rank it can change your position by thousands. Medicine is the key to doing well in the NEET PG exam, so it is very important to study Medicine properly.

What makes Medicine really tough is that it does not exist all by itself. Every question about Medicine is connected to Physiology and Pathology and Pharmacology. When you are asked about how to help a patient who has heart failure you need to know about the Frank-Starling mechanism which's part of Physiology and you need to know about the changes that happen in the heart when someone has dilated cardiomyopathy which is part of Pathology and you also need to know about Medicine and how to use beta-blockers and ACE inhibitors which is part of Pharmacology and Medicine. Medicine is connected to all these things.

Think of Medicine as the "integration center" of your MBBS knowledge. The examiners know this, and they exploit it beautifully.

Why Focus on High-Yield Topics?

The National Eligibility cum Entrance Test Post Graduate syllabus covers a lot of things. It has 19 subjects that are divided into three parts: preclinical, para-clinical and clinical domains.

The National Eligibility cum Entrance Test Post Graduate smart way to prepare is to find the topics. The National Eligibility cum Entrance Test Post Graduate has some topics that are more important than others. About 20 percent of the topics will have about 80 percent of the questions.

When we look at the questions from the PG 2025 exam, we can see a clear pattern. 30 Percent of the questions were either exactly the same or very similar to questions from previous years. The people who make the exam seem to like topics, and every year they ask a lot of questions from the same areas in Medicine. These areas are like spots for them, and they keep coming back to them year after year. The NEET PG 2025 questions show us that the examiners really like to focus on these high-yield zones in Medicine.

The recent shift toward clinical case-based questions means you can't just memorize Harrison's tables. You need to apply concepts to real patient scenarios — the kind you'll encounter in your internship and residency.

Top 10 High-Yield Medicine Topics for NEET PG 2026

Cardiology

• The Cardiology part of the exam always has around 8 to 10 questions. In the PG 2025 paper, they really focused on Cardiology. They asked a lot of questions about managing fibrillation and dealing with acute coronary syndrome. They also asked about how to classify heart failure in Cardiology.

Must-Know Concepts:

• Rate control vs. rhythm control in AF (beta-blockers first-line for stable AF)
• When it comes to STEMI management, the goal is to keep the door-to-balloon time under 90 minutes.
• The best approach for STEMI management is PCI, which is preferred.
• STEMI management is about being quick and using primary PCI.
• So we should try to keep the door-to-balloon time for STEMI management as short as possible, under 90 minutes, and use primary PCI for STEMI management.
• CHA₂DS₂-VASc scoring for anticoagulation decisions
• HFrEF vs. HFpEF management differences
• ECG interpretation: bundle branch blocks, axis deviation, ischemic changes

Clinical Pearl: When a patient who is stable has a problem with their heart beating too fast, which is called atrial fibrillation, the doctor should first give the patient a medicine called IV Metoprolol. The doctor should not try to fix the heart rhythm with a treatment called cardioversion, and the doctor should not give the patient a medicine called amiodarone. This is something that was actually on the PG 2025 test.

Also Read: Top 10 Most Demanding Branches of PG Medical Courses in India

Neurology

• People really like to learn about stroke management and epilepsy. The exam that happened in 2025 had a lot of questions, including thrombolysis criteria, which were a part of the test.

Must-Know Concepts:

• IV rtPA window: within 4.5 hours of symptom onset
• NIH Stroke Scale components
• To manage status epilepticus, we need to follow an order of medications. First, we use Lorazepam. If that does not work, we move on to Phenytoin. If the patient still has seizures, we try Levetiracetam. This is the order we follow for status epilepticus management: Lorazepam, then Phenytoin, and finally Levetiracetam.
• Parkinson's disease staging and drug selection
• Migraine: Sumatriptan for acute attacks, propranolol for prophylaxis
• High-Yield Numbers: rtPA dose is 0.9 mg/kg (max 90 mg), with 10% as bolus and 90% as infusion over 60 minutes.

Nephrology

• People with chronic kidney disease are at different stages. Chronic kidney disease and acid-base disorders happen a lot with kidney disease. You see kidney disease and acid-base disorders all the time when you have chronic kidney disease.

Must-Know Concepts:

• CKD staging based on GFR (known exact cutoffs: Stage 3a: 45-59, Stage 3b: 30-44)
• Anemia of CKD: Erythropoietin-stimulating agents when iron stores are adequate
• Anion gap calculation and interpretation (Normal: 8-12 mEq/L)
• HAGMA is a deal. It has a lot of causes. People use the MUDPILES mnemonic to remember what these causes are. The MUDPILES mnemonic is for HAGMA.
• M is for something that affects the body and causes HAGMA
• U is for another thing that can cause HAGMA
• D is for something that can cause HAGMA
• P is for something that happens and causes HAGMA
• I is for something that affects the body and causes HAGMA
• L is for something that can cause HAGMA
• E is for something that happens and causes HAGMA
• S is, for something that affects the body and causes HAGMA. The MUDPILES mnemonic helps people remember the causes of HAGMA. HAGMA is a thing, and the MUDPILES mnemonic is used to remember its causes.
• Dialysis indications: AEIOU (Acidosis, Electrolytes, Intoxication, Overload, Uremia)

Also Read: How to Prepare for NEET PG 2026 and Achieve a Score of 650+

 Endocrinology

• Doctors look at how to manage Diabetic Ketoacidosis and thyroid emergencies a lot. They have to know what to do when someone has Diabetic Ketoacidosis or a thyroid emergency. Diabetic Ketoacidosis and thyroid emergencies are very serious. Need to be treated right away.

Must-Know Concepts:

• DKA triad: Hyperglycemia + Ketosis + Acidosis
• DKA management: IV fluids → Insulin → Potassium replacement
• You should add dextrose when the blood glucose level gets to 200 mg/dL. This is a time to add dextrose to the blood. The blood glucose level is very important. You need to add dextrose when it reaches 200 mg/dL. Adding dextrose at this time will help the blood glucose level.
•  The blood glucose level is the thing to think about.
•  You need to add dextrose when the blood glucose level reaches 200 mg/dl
• The blood glucose level and adding dextrose are very important. You have to add dextrose when the blood glucose reaches 200 mg/dL.
• Thyroid storm management: PTU → Beta-blockers → Steroids → Iodine
• Adrenal crisis: stress-dose hydrocortisone (100 mg IV bolus)

 Pulmonology

Episodes of Chronic Obstructive Pulmonary Disease and taking care of Acute Respiratory Distress Syndrome. The management of Chronic Obstructive Pulmonary Disease exacerbations and Acute Respiratory Distress Syndrome is really important here. Chronic Obstructive Pulmonary Disease exacerbations and Acute Respiratory Distress Syndrome management are the things we are looking at in this section.

Must-Know Concepts:

• GOLD classification for COPD
• ARDS Berlin criteria: timing, chest imaging, origin of edema, oxygenation
• PaO₂/FiO₂ ratio interpretation (<300 mild, <200 moderate, <100 severe ARDS)
• Asthma stepwise management
• TB-HIV co-infection: when to start ART (within 2-8 weeks of ATT)

Gastroenterology

The doctors check the plans for treating liver and stomach problems carefully. They also make sure the plans for stopping stomach bleeding are good. The medical staff test these plans for liver and stomach problems and stomach bleeding to make sure they work well.

Must-Know Concepts:

• Child-Pugh scoring for cirrhosis prognosis
• Variceal bleeding management: octreotide + antibiotics + endoscopic banding
• H. pylori triple therapy: PPI + Clarithromycin + Amoxicillin (14 days)
• Acute pancreatitis severity: Ranson's criteria, APACHE II
• Inflammatory bowel disease differentiation (UC vs. Crohn's)

Hematology

Bleeding disorders and anemia classifications yield predictable questions.

Must-Know Concepts:

• Iron deficiency anemia: microcytic, low ferritin, high TIBC
• Vitamin B12 deficiency: macrocytic, neurological manifestations
• DIC: prolonged PT/PTT, low fibrinogen, elevated D-dimer
• ITP vs. TTP differentiation
• Hemophilia A vs. B: Factor VIII vs. IX deficiency

Rheumatology

Autoimmune conditions and their serological markers are high-yield.

Must-Know Concepts:

• Ankylosing spondylitis: HLA-B27, sacroiliitis, MRI for early diagnosis
• SLE: ANA screening, anti-dsDNA for activity monitoring
• Sjögren's syndrome: dry eyes + dry mouth + positive autoantibodies
• Dermatomyositis: heliotrope rash, Gottron's papules

Infectious Diseases

HIV management and tropical infections are things that doctors always check for. They want to make sure people with HIV management and tropical infections get the treatment. HIV management is very important. So are tropical infections. Doctors test for HIV management and tropical infections all the time to keep people healthy.

Must-Know Concepts:

• WHO clinical staging of HIV
• First-line ART regimens
• Opportunistic infections at various CD4 counts
• Malaria species differentiation and treatment
• Drug-resistant TB management

Also Read: Crafting a NEET PG Study Plan for Working Professionals

Emergency Medicine

People are really focusing on what happens when someone first gets very sick and how to help them recover. This is very important when it comes to presentations and resuscitation protocols. Doctors and nurses are learning more about how to deal with presentations, and they are getting better at using resuscitation protocols to save lives. Acute presentations and resuscitation protocols are crucial in emergency situations.

Must-Know Concepts:

• ACLS algorithms: VF/pVT, asystole, PEA
• Anaphylaxis: IM epinephrine first (0.3-0.5 mg)
• Sepsis bundles: 1-hour and 3-hour interventions
• We have some antidotes for poisoning. For paracetamol poisoning, we use NAC.
• For organophosphate poisoning, the antidotes are atropine and PAM.
• Glasgow Coma Scale interpretation

Subject-Wise Weightage Comparison

Also Read: Beginner Roadmap and Study Plan | NEET PG 2026

High-Yield Points for NEET PG 2026

• Cardiology alone contributes 8-10 questions — master AF management, ACS protocols, and heart failure drugs
• Image-based questions exceeded 50% in NEET PG 2025 — practice ECGs, X-rays, and CT scans extensively
• Clinical vignettes are the new normal — pure recall questions are decreasing
• Acid-base disorders appear every single year — know anion gap calculations cold
• Drug doses are frequently tested: rtPA (0.9 mg/kg), epinephrine for anaphylaxis (0.3-0.5 mg IM), hydrocortisone stress dose (100 mg IV)
• National health programs (WIFS, TB program updates) integrate into clinical questions
• Recent guidelines (ARDS Berlin criteria, sepsis definitions) are exam favorites
• Mnemonic for HAGMA causes: MUDPILES (Methanol, Uremia, DKA, Propylene glycol, Isoniazid/Iron, Lactic acidosis, Ethylene glycol, Salicylates)

Frequently Asked Questions

Which Medicine topics are most important for NEET PG 2026?

Cardiology, Neurology, Nephrology, and Endocrinology carry maximum weightage. Based on 2025 recalls, focus heavily on arrhythmia management, stroke protocols, CKD staging, and DKA treatment. These four subspecialties alone can yield 15-20 questions.

How many questions come from Medicine in NEET PG?

Medicine contributes approximately 40-45 questions out of 200, making it the highest-weighted subject at 20-22% of the paper. This includes General Medicine, Dermatology, Psychiatry, and related subspecialties.

Is Harrison's enough for NEET PG Medicine preparation?

Harrison's provides excellent conceptual depth, but it isn't sufficient alone. Supplement with PrepLadder video lectures for clinical integration, previous year question analysis, and image-based practice. Focus on Harrison's tables and flowcharts for quick revision.

What changed in the NEET PG 2025 Medicine pattern?

NEET PG 2025 showed increased clinical integration, with over 50% image-based questions. Pure recall MCQs decreased significantly. Questions required applying multiple concepts simultaneously — diagnosis, investigation, and management in a single vignette.

How should I prioritize Medicine topics in the last 3 months?

Dedicate 40% time to Cardiology + Neurology + Nephrology (highest yield). Spend 30% on Endocrinology + GI + Pulmonology. Reserve 30% for Rheumatology + Hematology + Infectious diseases. Practice 100-150 MCQs daily with timed conditions.

Are previous year questions repeated in NEET PG?

Approximately 30% of NEET PG 2025 questions were direct repeats or close variants of previous years and FMGE recalls. Solving the last 10 years' papers with explanations is non-negotiable. Focus on understanding why options are right or wrong.

CLINICAL PEARL

"In NEET PG, the patient in your question stem is your teacher. Read the vignette like you're at the bedside — age, risk factors, timeline, vitals, labs — every detail matters. The examiners aren't testing your memory; they're testing whether you can think like a clinician. Approach every question as if this patient is sitting in front of you.