Last 5-Year PYQs in Pharmacology for INI-CET

Pharmacology is one of the most scoring yet challenging subjects in INI-CET. Mastering it can significantly boost your rank and confidence. While the vast number of drugs, mechanisms, and classifications can feel overwhelming, your preparation doesn’t have to be.

The smartest way to streamline your prep is by focusing on Previous Years’ Questions. These questions help you spot trends, understand examiner preferences, and reinforce high-yield concepts effectively.

And here’s the good news—you don’t have to dig through multiple books or resources. We’ve compiled a curated list of high-yield Pharmacology PYQs from the last five years to help you revise smarter, not harder.

Let’s jump in and make Pharmacology your strength for INI-CET success.

Q1. Which of the following is the false statement regarding statins?

1.  Although HMG-CoA reductase inhibitors substantially reduce the risk of cardiovascular events, there is a mild increase in lipoprotein a (Lpa) levels.
2. These drugs should not be stopped even in severe conditions like injury, surgery etc.
3.  They can be given with verapamil and other enzyme inhibitors
4.  With long-term use, there is a slight increase in the incidence of type 2 diabetes mellitus.

Answer. 3.  They can be given with verapamil and other enzyme inhibitors

Q2. A young man sustained a scorpion sting 2 hours ago. On examination, his blood pressure is 168/100 mm Hg; HR, 72 beats/minute and respiratory rate, 32 breaths/ minute. He also complains of breathlessness. How do you manage this patient?

1. Metoprolol
2.  Ivabradine
3.  Prazosin
4. Frusemide

Answer: 3. Prazosin

Q3. Match the following drugs in Column A with their contraindications in Column B.

Column A	Column B
1. Morphine 2. Amiodarone 3. Vigabatrin 4. Estrogen preparations	1. QT prolongation 2. Thromboembolism 3. Pregnancy 4. Haad injury

1. A-1, B-3, C-2, D4
2.  A-4, B-1,C-3, D-2
3. A-2, B-4, C-1, D-3
4. A-3, B-2, C-4, D-1

Answer: 2.  A-4, B-1,C-3, D-2

Q4. A man was brought to the emergency room after poisoning with an unknown substance. Muscarinic poisoning was suspected, and he was treated for the same. What is the possible presenting feature that led to the diagnosis?

1. Mydriasis
2. Diuresis
3. Muscle fasciculations
4. Bradycardia

Answer. 4) Bradycardia

Q5. A patient was diagnosed with pulmonary tuberculosis and was started on first-time antitubercular drugs. Which of the following drugs acts by inhibiting the synthesis of the marked layer shown in the image?

1. Isoniazid
2. Rifampicin
3.  Pyrazinamide
4.  Ethambutol

 Answer 1) Isoniazid

Q6. A patient is on phenytoin for a seizure disorder. He was prescribed sucralfate four times a day for peptic ulcer. What should be the minimum duration of time between consumption of these drugs?

1. 30 minutes
2. 60 minutes
3. 90 minutes
4.  120 minutes

Answer: D) 120 minutes

Q7. Which of the following is not an off-label use of risperidone?

1.  Obsessive impulsive disorder
2.  Dementia
3.  PTSD
4. Bipolar disorder

 Answer: D) Bipolar disorder

Q8. If the dosage of a drug following first-order kinetics is doubled, how would it affect the half-life and plasma concentration?

1. Half-life doubles, and plasma concentration remains the same
2. Half-life remains the same and plasma concentration doubles
3. Half-life and plasma concentration remain the same
4.  Half-life and plasma concentration doubles

 Answer: 2) Half-life remains the same ,and plasma concentration doubles

Q9. Which of the following diseases does not involve the use of antimicrobial combinations?

1. Uncomplicated gonorrhea
2. Tuberculosis 
3. Intra-abdominal infections
4. Malaria

 Answer: 1) Uncomplicated gonorrhea

Q10. The dose at which dopamine acts on beta-1 receptors is _________?

1. 2-10 mcg/kg/min
2. <2 mcg/kg/min
3. 10-20 mcg/kg/min
4. >20 mcg/kg/min

  Answer: 1) 2-10 mcg/kg/min

Q11. Which among the following anti-leprosy drugs can cause skin hyperpigmentation?

1. Clofazimine
2. Rifampicin
3. Dapsone
4. Ofloxacin

 Answer. 1 ) Clofazimine

Q12. Which among the following is an HER-1 inhibitor?

1. Panitumumab
2. Crizotinib
3. Alectinib
4. Lorlatinib

Answer: 1) Panitumumab

Q13. Identify the Pcsk9 inhibitor.

1. Evolocumab
2. Lomitapide
3. Mipomersen
4. Torcetrapib

 Answer : 1 ) Evolocumab

Q14. Which of the following diuretics is matched correctly with its primary site of action?

1) Osmotic diuretics - Distal convoluted tubule.
2) Thiazide diuretics - Proximal convoluted tubule
3) Carbonic anhydrase inhibitors - Proximal convoluted tubule
4) Potassium-sparing diuretics - Collecting duct.

1. 1, 2, and 3
2. 3 and 4
3.  2, 3, and 4
4.  1 and 2

Answer: 2) 3 and 4

Q15. Which of the following adverse effects prevents the use of Teriparatide in a patient with Paget’s disease?

1. Osteonecrosis of jawbone
2. Osteosarcoma
3. Subtrochanteric fractures
4. Net loss of bone mass

 Answer: 2) Osteosarcoma

Q16. Which of the following is not a use of enteric-coated drugs?

a) Protect the acid-labile drug from gastric acidity

b) Protect the gastric mucosa from the irritant effects of certain drugs

c) Prolongs the half-life of the drug

d) Deliver drugs distal to the stomach

1. a, b & c
2. b, c & d
3.  a, c & d
4.   c

 Answer 4 ) C

Q17. Which of the following side effects are likely to be observed when a patient already taking metoprolol is prescribed verapamil?

a) Bradycardia with Av Block
b) Torsades De Pointes
c) Tachycardia
d) Ventricular Fibrillation

1. a only
2. a & b
3.  a & c
4.  b & d

 Answer 1) a only

Q18. Which of the following drugs should not be combined with rosuvastatin?

1.  Oxycodone
2.  Clarithromycin
3.  Adalimumab
4.  Rivaroxaban

  Answer 2) Clarithromycin

Q19. Which topical antifungal exhibits both anti-inflammatory properties and provides relief from itching?

1.  Ketoconazole
2.  Sertaconazole
3.  Luliconazole
4.  Terbinafine

 Answer 2)- Sertaconazole

Q20. For a patient who has commenced lithium therapy, which of the following adverse effects should they be instructed to be vigilant for in order to detect any signs of toxicity?

1. Malaise and sore throat
2. Vertigo and Diarrhoea
3. Fever
4. Breathlessness

Answer: 2) Vertigo and Diarrhoea

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