Jun 3, 2025
Dose-dependent toxicity
Dose-independent/idiosyncratic
Laboratory findings
Categories of Aplastic Anemia
Progression to malignancy
Newer Therapies for Refractory AA
Prognosis
Often caused by various external insults. Incidences like western countries have 2-6 cases/million population/year. In Asia, there are a higher number of incidents. In Japan it was noticed up to 14-15 cases/million population/year. Mechanism implicated:
Rarely acquired AA as compared to IBMFSs. But can happen, especially if G-CSF used > 7 days.
Spontaneous recovery from pancytopenia rarely occurs. If left untreated, severe pancytopenia has an overall mortality rate of approximately 50% within 6 months of diagnosis and of >75% overall. Infection and hemorrhage are the major causes of morbidity and mortality. Children responding to HSCT and/or immunosuppressive regimens early usually have a good outcome. 65-70% have good survival if they come to early attention.
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