Most IMP Biochemistry PYQs for FMGE July ‘23

Here’s the trick you need to remember while solving PYQs:

Focus on the related topics, not just the question itself. 

PYQs are critical in all competitive exams. However, for FMGE they are critical because the FMGE consists of a lot of repeat questions. 

At the same time, you must understand that ‘repeat questions’ does not necessarily mean a direct repeat of the same question in the exact form. 

Most of the time, it means that a different question has been asked but from the same topic. This is why you must focus on the related topics while solving a PYQ. While going through the questions of Biochemistry given below, keep the above facts in mind. 

As our star faculty Dr. Shanmugapriya says, if you can master the given topics below, you will be able to attempt any Biochemistry question confidently in the exam. 

Let’s begin.

A 25 year old male returing from China was found to have fever. What is the specific diagnostic test that needs to be performed?

1. ELISA
2. d dimer
3. CRP
4. RTPCR

Answer: RTPCR

A person has a history of alcoholism for 20 years. He avoids alcohol for 2 days and presents with agitation, global confusion, disorientation, hallucination, fever, high BP, diaphoresis and autonomic hyperactivity. The most common cause is:

1. Delirium tremens
2. Wernicke's encephalopathy
3. Korsakoff syndrome
4. Pancreatitis

Answer: Delirium tremens

Q3-The neutral lipid which is stored in liver is:

1. Triacylglycerol
2. Cholesterol
3. Phospholipids
4. Fatty acids

Answer: Triacylglycerol

A 2 month old boy presented with ambiguous genitalia. His blood pressure was normal. The DHT value was low. The probable diagnosis is

1. 21 beta hydroxylase deficiency
2. 11 beta hydroxylase deficiency
3. 17 alpha hydroxylase deficiency
4. 3 beta hydroxy steroid dehydrogenase deficiency

Answer: 17 alpha hydroxylase deficiency

A 25 year old male presents with hypercholesterolemia. His elder brother has also died of a heart disease a few years back. LDL receptor defect was observed. What is the most probable cause?

1. Abetalipoproteinemia
2. Familial Hypercholesterolemia
3. Familial Combined Hyperlipidemia
4. Apo E deficiency

Answer: Familial Hypercholesterolemia

Q3 -Drug of choice in mountain sickness

1. Thiazides
2. Frusemide
3. Acetazolamide
4. Spironolactone

Answer: Acetazolamide

Q5-Fat sugar baby is seen in?

1. Kwashiorkor
2. Marasmus
3. - Diabetes
4. Hypothyroidism

Answer: Kwashiorkor

Q. A boy presents with voracious apetite and overall swelling. He is mostly suffering from?

1. Marasmus
2. Kwashiorkor
3. Marasmic Kwashiorkor
4. Obesity

Answer: Marasmic Kwashiorkor

Q6-Which of the following has the lowest glycemic index?

1. Potato
2. Sweet corn
3. Water melon
4. Papaya

Answer: Sweet corn

Q7-The micronutrient that is deficient following post ileal resection is?

1. B12
2. Folate
3. Iron
4. copper

Answer: B12

Q8-A Vegetarian patient presents with anemia & hypersegmented neutrophil. The most probable cause is?

1. Megaloblastic anemia
2. iron deficiency anemia
3. Anemia of chronic disease
4. Sideroblastic anemia

Answer: Megaloblastic anemia

Q9-A person presents with diarrhea, dementia and dermatitis. What is the probable cause?

1. Pellagra
2. Cystinuria
3. Alkaptonuria
4. Porphyria

Answer: Pellagra

Q10-Menke's disease is caused by?

1. Copper deficiency
2. Copper toxicity
3. Zinc deficiency
4. Flurine excess

Answer: Copper deficiency

Q11-Cholesterol is synthesized from?

1. Acetyl CoA
2. Bile acid
3. Phenylalanine
4. Heme

Answer: Acetyl CoA

Q12-What happens after a meal?

1. Increase in Insulin and decrease in Glucagon
2. Increase in glucagon and increase in Insulin
3. No changes in both
4. Decrease in Insulin and Glucagon

Answer: Increase in Insulin and decrease in Glucagon

Q14-Which of the following activities are low in riboflavin deficiency?

1. Transketolase
2. Glycogen phosphorylase
3. Propionyl CoA carboxylase
4. Glutathione reductase

Answer: Glutathione reductase

Q. The enzyme that is released in hypothalamus is?

1. Hexokinase I
2. Hexokinase II
3. Hexokinase III
4. Hexokinase IV

Answer: Hexokinase IV

Q. A postmenopausal woman presents with pain in the first metatarsophalangeal join following intake of alcohol. The drug used should act by inhibiting which of the following enzymes?

1. Xanthine Oxidase
2. Thymidylate synthase
3. HGPRTase
4. Adenosine deaminase

Answer: Xanthine Oxidase

Q. Peripheral conversion of T4 to T3 is done by?

1. Tyrosinase
2. Thyroid peroxidase
3. TRH
4. Deiodinase

Answer: Deiodinase

Q. A midde aged patient presented with high anion gap metabolic acidosis and is diagnosed with defect of PDH complex. Which of the following dietary advice would you prescribe?

1. Only carbohydrate intake henceforth
2. High carbohydrate low fat intake
3. High fat low carbohydrate diet
4. High protein low carbohydrate diet

Answer: High fat low carbohydrate diet

Before you move on to the next PYQ, here’s the FMGE Flashback video of Dr. C. Shanmugapriya for Biochemistry. Watch the entire video to deepen your understanding because Dr. Shanmugapriya explains both the correct and incorrect options along with the related topics.

Q. In liver ApoB gene is completely translated to Apo B100 and in intestine, it is translated to apo B48. Which of the following mechanisms explains this?

1. RNA editing
2. Gene splicing
3. Alternative polyadenylation
4. Gene rearrangements

Answer: RNA editing

Q. ANP acts through?

1. cGMP
2. CAMP
3. IP3 DAG
4. Tyrosine kinase

Answer: cGMP

Q. Which of the following pathways only takes place in a cell's cytoplasm?

1. Glycolysis
2. Beta oxidation
3. TCA
4. Urea cycle

Answer: Glycolysis

Q. Which of the following is not a microelement?

1. Copper
2. Calcium
3. Zinc
4. Selenium

Answer: Calcium

Q. Melanin is synthesized from which of the following amino acid?

1. Tyrosine
2. Tryptophan
3. Leucine
4. Phenylalanine

Answer: Tyrosine

Q. Given picture depicts the deficiency of?

1. Niacin
2. Retinol
3. Riboflavin
4. Tyrosine

Answer: Niacin

Q. A child presents with complaints of urine turning dark on standing. It is caused by the deficiency of?

1. Branched chain ketoacid dehydrogenase
2. Isovaleryl CoA dehydrogenase
3. Glutathione synthetase
4. Homogentisate oxidase

Answer: Homogentisate oxidase

While this blog only covers the Most important Biochemistry PYQs, we've also crafted an extensive post encompassing previous year FMGE question papers for the past three exams. PDFs of FMGE Previous Year Question papers are also available to help you strengthen your exam readiness.

Q. Which of the following is a complex IV inhibitor of ETC?

1. Cyanide
2. Amobarbital
3. TTFA
4. 2,4 Dinitrophenol

Answer: Cyanide

Q. Which of the following enzyme is found to be deficient in Von Gierkes disease?

1. Glucose 6 phosphatase
2. Branching enzyme
3. De-Branching enzyme
4. Myophosphorylase

Answer: Glucose 6 phosphatase

Q. Which of the following plays a role in collagen maturation?

1. Copper and Zinc
2. Copper and Ascorbic acid
3. Proline
4. Phenylalanine

Answer: Copper and Ascorbic acid

Q. Deficiency causing tingling sensation?

1. Folic acid
2. Thiamine
3. Niacin
4. Riboflavin

Answer: Thiamine

Q. Which immunoglobulin is present in serum/plasma at the highest concentration?

1. IgG
2. IgA
3. IgM
4. IgE

Answer: IgG

Q. Nitric oxide is formed from which amino acid?

1. Arginine
2. Lysine
3. Tryptophan
4. Leucine

Answer: Arginine

Q. A patient presented to the OPD with liver damage. The picture depicts the patient having their eyes examined. Which of the subsequent factors is the cause of this condition?

1. Copper
2. Glucose
3. Galactose
4. Mannose

Answer: Copper

Q. Breastfeeding is contraindicated in which of the following conditions?

1. Galactosemia
2. CMV
3. Hepatitis B
4. West Nile Virus

Answer: Galactosemia

Q. A patient presented to the OPD with complaints of Diarrhea. The patient was later diagnosed with dementia and photosensitive dermatitis in sun- exposed areas. Which Vitamin deficiency is responsible for this condition?

1. Vitamin B6
2. Niacin
3. Ascorbic acid
4. Biotin

Answer: Niacin

Q. A woman with complaints of pain, tingling sensation, and numbness of the foot has a history of taking vitamin supplements. Which of the following is responsible for this patient's condition?

1. Hypervitaminosis B6
2. Beri-Beri
3. Increased Vitamin B12
4. Vitamin A toxicity

Answer: Hypervitaminosis B6

Q. Vitamin A deficiency leads to?

1. Xerophthalmia
2. Beri-Beri
3. Pellagra
4. Neuropathy

Answer: Xerophthalmia

Q. Cytochrome P450 is associated with?

1. NADH
2. NADPH
3. FADH2
4. ADP

Answer: NADPH

Q. What kind of inhibition does this graph depict?

1. Competitive Inhibition
2. Uncompetitive Inhibition
3. Non-competitive Inhibition
4. Mixed Inhibition

Answer: Non-competitive Inhibition

Q. Which of the following is cardipreotective?

1. Omega 6 fatty acids
2. Omega 3 fatty acids
3. Omega 9 fatty acids
4. Saturated fatty acids

Answer: Omega 3 fatty acids

And that sums up the most important FMGE PYQs for Biochemistry by our star faculty, Dr. C. Shanmugapriya. 

With less than 20 days to go for the FMGE July ‘23 exam, it is time to make your PYQ preparation airtight. PYQs alone can help you crack 150+ in the FMGE July 2023. 

Go through all the questions carefully and remember to learn the related topics surrounding the question. 

All the best for your preparation. 

Team PrepLadder.