Feb 15, 2023
Neuromuscular blocking agents, also known as muscle relaxants, play a crucial role in the field of anesthesia. Neuromuscular blockers are essential for various surgical procedures, as they allow for a patient to remain immobile and without pain during surgery. A good understanding of neuromuscular blockers is important for a comprehensive understanding of anesthesia and its role in surgical procedures.
In this blog post, we discuss this important anesthesia topic briefly for the NEET PG/NExT exam Preparation. Read on.
Depolarizing | Non - Depolarizing |
Succinylcholine | Rest All |
Persistent / prolonged depolarization of Nc (Nicotinic cholinergic Receptor). | Acts by Competitive antagonism. |
Fasciculation is seen. Postoperative myalgia may be seen. Not reversed by the Neostigmine. No post tetanic facilitation seen. | No fasciculations seen. No myalgia seen. Reversal by Neostigmine. post tetanic facilitation seen. |
Depolarising | Non-Depolarising | ||
Aminosteroids | Benzylisoquinolines | Oximes | |
Succinylcholine | Pancuronium | D-tubocurarine | Gantacurium |
Pipecuronium | Doxacurium | ||
Vecuronium | Atracurium | ||
Rocuronium | Cis-atracurium | ||
Rapacuronium | Mivacurium |
Depolarizing | Definition | Non - Depolarizing |
MoAProlonged or persistent depolarization of nicotinic cholinergic receptor Causes: Depolarization | Competitive inhibition | |
Fasciculation are seen | - | No Fasciculations |
Lesser amplitude of contraction produced. | - | It will fade. |
Post-operative myalgia | - | No Postoperative myalgia |
Not reversed by Neostigmine | - | Reversed by Neostigmine |
No post tetanic fasciculation seen | - | Post tetanic fasciculation seen |
No train of 4 responses was seen. A - Response by First stimulus. B - Response by Last stimulus. BA = TOF Ratio TOF ratio = 1.Neuromuscular monitor is not used. | 4 successive stimuli given at 2 Hz at the same interval of time i.e., 0.5 sec and of same amplitude. In normal muscle it will produce 4 contractions. | TOF Ratio < 1 Neuromuscular monitor is used. |
Also Read: Drugs for General Anesthesia - NEET PG Anesthesia
Also Read: Alternative Airway Devices and Adjuncts - NEET PG Anesthesia
Aminosteroids | Benzylisoquinolines | |
PancuroniumPipecuronium | Long Acting | d- tubocurarineDoxacurium |
Rocuronium M/c usedVecuronium | Intermediate Acting | Atracurium Cis-atracurium |
Rapacuronium(Faster onset) | Short Acting | Mivacurium (Shortest Duration) |
No Histamine Release CVS Stable | - | Histamine Release CVS Unstable BronchospasmBP ↓HR ↑Flushing |
Metabolized by liver, kidney | - | Few drugs have unique Metabolism as given below |
Important Information
Rest all have 3 – 5 min onset
A. Less histamine release
B. Less half life
C. Low Drug Dose
D. Low cost
A. Neostigmine
B. Carbachol
C. Succinylcholine
D. Physostigmine
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