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May 22, 2017
IMPORTANT TOPICS IN PHARMACOLOGY |
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TOPIC | MUST KNOW | DESIRABLE TO KNOW | |
GENERAL | pH, pKa, ionization Bioavailability First pass metabolism Vd PPB Prodrugs CYP substrates, inducers, inhibitors Metabolic reactions Formulas | First and zero order kinetics TDM Receptors types and examples DRC Pharmacogenetics Clinical trials Drug labels Orphan drugs Essential drugs | Enzyme inhibition (competitive, non-competitive and uncompetitive) Types of antagonists Pharmacovigilance Evidence based medicine |
ANS | AChE inhibitors OP Poisoning Sympathetic receptors location | Catecholamines table Beta blockers Anticholinergics | Alpha blockers Glaucoma Rabbit practicals |
AUTACOIDS | Antihistaminics PCM and aspirin poisoning | DMARDs Gout Migraine | PG actions Other NSAIDs |
CVS | Digoxin New drugs for CHF Drugs decreasing mortality in CHF | JNC 8 guidelines for hypertension New antianginal drugs Statins | Pulmonary hypertension Antiarrhythmics New hypolipidemic drugs |
KIDNEY | K sparing diuretics | - | Free water clearance Vasopressin antagonists |
ENDOCRINE | Somatostatin GnRH agonist and antagonist New antidiabetic drugs | Osteoporosis SERM OCPs Mifepristone | Antithyroid drugs Oral hypoglycemic agents Adverse effect of steroids SPRM Anti-androgens |
CNS | Short acting BZD Parkinsonism Multiple sclerosis Antiepileptic drugs | Antipsychotic names and adverse effects SSRI and SNRI TCA poisoning Lithium and mania | Newer hypnotic drugs MAO inhibitors Opioids |
ANAESTHESIA | Local anaesthetics mechanism and special points SCh and NDMRs MAC and Bld gas partition coefficient | Colour coding of cylinders Pin index system Xenon Halothane Ketamine | Spinal anaesthesia Neurolept analgesia |
HEMATOLOGY | Anticoagulants specially new | Antiplatelets Fibrinolytics | Iron deficiency anemia Growth factors |
RESPIRATORY | Bronchodilators | DOC for different asthma types | Theophylline |
GIT | Peptic ulcer | Crohn’s and Ulcerative colitis | Metaclopramide, domperidone IBS |
ANTIMICROBIALS | Important points (Review of Pharmacology 11th edition/page:380-382) Tuberculosis with RNTCP Malaria | Mechanism of drug resistance Beta lactams Aminoglycosides Fluoroquinolones HIV Hepatitis C | Tetracyclines Macrolides Cotrimoxazole Leprosy Antifungal |
ANTICANCER | CCS and Non-specific drugs General and specific adverse effects of anticancer drugs (Specially chemo-man cartoon) | Monoclonal antibodies Tyrosine kinase inhibitors Newer anticancer drugs | - |
IMMUNOLOGY | Cyclosporine Tacrolimus | Monoclonal antibodies Thalidomide | - |
SPECIAL TOPICS | New drugs approved in last 12 months (uses only) Anti-obesity drugs | Erectile dysfunction Anti-smoking drugs Treatment of HIT Treatment of hyperkalemia | - |
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