Last 5 Years PYQs INI-CET Biochemistry
Jan 30, 2025

Download Last 5-Year INI-CET PYQs – Subject-wise PDFs
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Q1. What is true about the Hayflick limit?
- Human cells can divide a finite number of times only
- Free radical oxidation level is unrestricted
- Telomerase activity is restricted.
- RNA polymerase can function for a finite amount of time only
Ans. 1) Human cells can divide a finite number of times only
Q2. DNA methylation not related to?
- Mismatch repair
- Chromatin remodeling
- DNA replication
- Gene silencing
Ans. 3) DNA replication
Q3. The correct order of steps in a polymerase chain reaction (PCR) is:
- Hybridization, annealing, elongation, denaturation
- Elongation, denaturation, Hybridization, annealing,
- Denaturation, annealing, extension.
- Annealing, extension, denaturation
Ans. 3) Denaturation, annealing, extension
Also read: Biochemistry Important Questions For NEET PG/FMG Exams
Q4. The meal that exhibits the highest thermic effect is characterized by
- Protein
- Fat
- Carbohydrates
- Mixed meal having all 3 in equal amount
Ans. 1) Protein
Q5. The sequence of vitamin D synthesis is?
- Liver-skin-kidney
- Skin-liver-kidney
- Skin-kidney-liver
- Liver-kidney-skin
Ans. 2) Skin-liver-kidney
Q6. How does RNAi impact gene expression?
- Knock out
- Knockdown
- Knock up
- Knock in
Ans. 2) Knockdown
Q7. Which of the following poisoning agents does not inhibit cytochrome oxidase?
- Hydrogen sulfide
- Carbon monoxide
- Methane
- Cyanide
Ans. 3) Carbon monoxide
Also read: Important Questions On Carbohydrate Chemistry
Q8. Which of the following lipase enzymes is inhibited by the insulin?
- Lipoprotein lipase
- Pancreatic lipase
- Gastric lipase
- Hormone-sensitive lipase
Ans. 4) Hormone sensitive lipase
Q9. What is the main substrate and metabolic fuel used by RBCs during fasting period?
- Ketone bodies
- Glucose
- Free fatty acids
- Amino acids
Ans. 2) Glucose
Q10. Which of the following diagnostic markers is/are not correctly matched?
| 1. Beta-glucocerebrosidase | Von Gierke disease |
| 2. Lipase | Acute pancreatitis |
| 3. Ceruloplasmin | Hepatolenticular degeneration |
| 4. High LDH1: LDH2 ratio | Myocardial infarction |
- 1 only
- 1 and 2
- 1, 2 and 4
- 2, 3 and 4
Ans. 1) 1 only
Q11. In a patient with maple syrup urine disease, all of the following amino acids should be restricted in diet, except?
- Methionine
- Valine
- Leucine
- Isoleucine
Ans. 1) Methionine
Also read: Last 5 year PYQs in Psychiatry for NEET PG
Q12. Affinity maturation of antibodies is because of ____.
- Somatic hypermutation
- Differential mRNA processing
- CD40
- Gene rearrangements
Ans. 1) Somatic hypermutation
Q13. The best method for the detection of mutations with low allele frequency is:
- Droplet digital PCR
- FISH
- Nested PCR
- Sanger sequencing
Ans. 1) Droplet digital PCR
Q14. Deamination of methylated cytosine forms which of the following?
- Uracil
- Cytosine
- Guanine
- Thymine
Ans. 4) Thymine
Also read: Important Topics in Biochemistry for NEET-PG
Q15. Which of the following options best describes the mutation seen in patients with cystic fibrosis?
- Tryptophan at 708 position, chloride channel
- Phenylalanine at 708 position, calcium channel
- Phenylalanine at 508 position, chloride channel
- Tryptophan at 508 position, calcium channel
Ans. 3) Phenylalanine at 508 position, chloride channel
Q16. Which of the following enzyme defects leads to Pompe’s disease?
- Lysosomal acid alpha glucosidase
- β-hexosaminidase-A
- Β–galactocerebrosidase
- β-glucocerebrosidase
Ans. 1) Lysosomal acid alpha glucosidase
Q17. Xanthurenic aciduria may be treated with high doses of which vitamin
- Vitamin B6
- Vitamin B12
- Vitamin B5
- Vitamin B7
Ans. 1) Vitamin B6
Also read: Last 5 Year PYQs in ENT for NEET PG
Q18. Deficiency of which of the following causes Barth syndrome?
- Cardiolipin
- Sphingomyelin
- Glycolipids
- Cerebroside
Ans. 1) Cardiolipin
Q19. What determines the DNA sequence?
- Flow cytometry
- FISH
- RFLP
- PCR
Ans. 4) PCR
Q20. Calculate Anion Gap ?
Na: 145 mmol/L
K: 4 mmol/L
CI: 90 mmol/L
HCO3 : 15mmol/L
- 35
- 40
- 28
- 12
Ans. 2) 40
Also read: Last 5 Years PYQs of INI CET Dermatology
Q21. Ketosis is common in type 1 DM due to:
- Decreased beta-oxidation of fatty acids
- Increased mobilization of fat from the adipose cell
- Decreased acetyl CoA in TCA cycle
- Increase beta-hydroxy butyryl synthase
- 1, 2, and 3
- 1, 2, 3, and 4
- 4 only
- 1 and 2 only
Ans. 1) 1, 2, and 3
Q22. Which type of DNA repair mechanism involves the removal and replacement of a damaged DNA strand with the help of an undamaged complementary strand as a template?
- Base Excision Repair
- Nucleotide Excision Repair
- Mismatch Repair
- Homologous Recombination
Ans. 4) Homologous Recombination
Q23. What is the enzyme that is shared by both glycolysis and gluconeogenesis?
- Pyruvate kinase
- Phosphofructokinase
- Phosphoenolpyruvate carboxy kinase
- Phosphoglycerate kinase
Ans. 4) Phosphoglycerate Kinase
Also read: Last 5 Year PYQs in Pathology for NEET PG
Q24. Out of the enzymes listed below, which one exhibits the greatest catalytic efficiency?
- Km of an enzyme = 10 micromole and Kcat = 20 per sec
- Km of an enzyme = 2000 nanomole and Kcat = 50 per sec
- Km of an enzyme = 2 micromole and Kcat = 200 per sec
- Km of an enzyme = 4 micromole and Kcat = 200 per sec
Ans. 3) Km of an enzyme = 2 micromole and Kcat = 200 per sec
Q25. What does IDA stand for and how is it interpreted in the medical field?
- Low serum ferritin
- Low transferrin saturation
- Increased TIBC
- All of the above
Ans. 4) All of the above
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