Last 5-Year PYQs in Physiology for FMGE

When it comes to preparing for FMGE, there is no smarter way to understand exam patterns, identify high-yield topics, and refine your strategy than solving previous years’ questions (PYQs).

Physiology, being a core subject in pre-clinical sciences, lays the foundation for your clinical understanding. It demands strong conceptual clarity and logical reasoning, making it both scoring and essential.

But what if you had access to the most frequently asked questions from the last five years? That’s exactly what this blog offers.

We’ve compiled high-yield Physiology PYQs that have been repeatedly tested in FMGE, along with detailed explanations to help you strengthen your basics, correct misconceptions, and improve your long-term retention.

Download FMGE Last 5-Year PYQs – Subject-wise PDFs

FMGE Last 5-Year PYQs Dermatology PDF	FMGE Last 5-Year PYQs Biochemistry PDF	FMGE Last 5-Year PYQs Anatomy PDF
FMGE Last 5-Year PYQs Anesthesia PDF	FMGE Last 5-Year PYQs Pediatrics PDF	FMGE Last 5-Year PYQs Ophthalmology PDF
FMGE Last 5-Year PYQs Microbiology PDF	FMGE Last 5-Year PYQs Medicine PDF	FMGE Last 5-Year PYQs OBG PDF
FMGE Last 5-Year PYQs FMT PDF	FMGE Last 5-Year PYQs ENT PDF	FMGE Last 5-Year PYQs Physiology PDF
FMGE Last 5-Year PYQs Pathology PDF	FMGE Last 5-Year PYQs Pharmacology PDF	FMGE Last 5-Year PYQs PSM PDF
FMGE Last 5-Year PYQs Surgery PDF	FMGE Last 5-Year PYQs Radiology PDF	FMGE Last 5-Year PYQs Orthopaedics PDF
FMGE Last 5-Year PYQs Psychiatry PDF

Let’s dive right in and level up your Physiology prep for FMGE 2025!

Q1. Which of the following describes the chloride ion exchange in red blood cells, where bicarbonate ions are exchanged for chloride ions to maintain electrical neutrality?

1. Haldane effect
2. Root effect
3. Bohr effect
4. Chloride shift

 Answer: 4) Chloride shift

Q2. Which of the following factors causes a rightward shift in the oxygen-hemoglobin dissociation curve?

1.  Increase in CO₂
2.  Increase in O₂
3.  Decrease in CO₂
4.  Decrease in temperature

Answer: 1) Increase in CO₂

Q3. Which electrolyte abnormality will lead to cardiac arrhythmia in patients with severe vomiting?

1. Hypokalemia
2. Hyponatremia 
3. Hyperkalemia
4. Hypocalcemia

 Answer: 1) Hypokalemia

Q4. A patient presents with high blood pressure accompanied by a decrease in heart rate. What is the most likely physiological mechanism responsible for this response?

1. Stimulation of baroreceptors
2. Inhibition of baroreceptors
3. Bezold-Jarisch reflex (J reflex)
4. Stimulation of chemoreceptors

 Answer: 1) Stimulation of baroreceptors

Q5. In the jugular venous pressure (JVP) waveform, the "a" wave corresponds to:

1. Right Atrial contraction
2. Tricuspid valve bulging into Right atria
3. Right Atrial relaxation
4. Right atrial filling

Answer: 1) Right Atrial contraction

Q6. Thyroid hormone acts via which type of receptor?

1. Cytoplasmic
2. Tyrosine kinase
3. Nuclear
4. GPCR

Answer 3 - Nuclear

Q7. What would be the least likely condition to happen if a group of colleagues took an excursion to a high altitude-mountain region?

1. Increase PaO2
2. Increase in RBC & Hb
3. Increased mitochondria
4. Hyperventilation

 Answer: 1 - Increase PaO2

Q8. Which co-transporter is primarily responsible for facilitating glucose absorption across the basolateral membrane of an enterocyte in this scenario?

1. SGLT1
2. GLUT2
3. GLUT5
4.  SGLT2

Answer:  2 - GLUT2: 

Q9. IV irritants were given as a result bradycardia,hypotension and apnea was developed. This represents which one of the following reflexes?

1. Bezold jarisch reflex
2. Bainbridge reflex
3. Cushing reflex
4. None of them

 Answer:  1) Bezold-Jarisch reflex

Q10. Which of the following functions is NOT attributed to the intestinal epithelium?

1. Absorption of the ions
2. Bile salts secretion
3. Mucous secretion
4. Secretion of digestive enzyme

 Answer: 2 - Bile salts secretion

Q11. Glucose is reabsorbed in which part?

1.  Proximal convoluted tubule
2.  Proximal straight tubule
3.  Collecting duct
4.  Distal convoluted tubule

 Answer: 1 - Proximal convoluted tubule

Q12. Which of the following options has the lowest concentration in intracellular fluid (ICF)compared to extracellular fluid?

1. Calcium
2. Magnesium
3. Potassium
4. Protein

Answer: 1 - Calcium

Q13. What is the term used to describe the opposition to passive stretching?

1. Tone
2. Spasticity
3. Rigidity
4. Paratonia

 Answer:  2. Spasticity

Q14. Enterokinase is an activator of?

1. Trypsinogen
2. Trypsin
3. Chymotrypsin
4. Antitrypsin

 Answer  1: Trypsinogen

Also read: Last 5 Year PYQs in Pediatrics for FMGE

Q15. What is the connecting structure between Broca's area and Wernicke's area?

1. Arcuate fasciculus
2. Anterior commissure
3. Corpus callosum
4. Fornix

Answer : 1 - Arcuate fasciculus

Q16. What is the primary protein that binds to thyroxine?

1. Follistatin
2. Transthyretin
3. Thyroxine-binding globulin
4. Transferrin

Answer: 3) Thyroxine-binding globulin

Also read: Last 5 Year PYQs in Ophthalmology for FMGE​

Q17. What is the accurate order of muscle utilization during ejaculation?

1. Ischiocavernosus relaxation-external urethral sphincter relaxation-Bulbospongiosus contraction
2. Ischiocavernosus relaxation-External urethral sphincter contraction-Bulbospongiosus relaxation
3. Ischiocaveernosus contraction- external urethral sphincter relaxation- Bulbospongiosus relaxation
4. Ischiocavernosus contraction- External urethral sphincter relaxation- Bulbospongiosus relaxation

 Answer: 3) Ischiocaveernosus contraction- external urethral sphincter relaxation- Bulbospongiosus relaxation

Q18. Oxytocin plays a role in-

1. Milk production
2. Milk ejection
3. Milk storage
4. Osmoregulation

 Answer: 2) Milk ejection

Also read: Last 5 Year PYQs in Microbiology for FMGE

Q19. What does the image below represent in terms of murmurs?

1. End diastolic
2. Pan systolic
3. Ejection systolic
4. Mid diastolic

 Answer: C) Ejection systolic

Q20. Which of the following statements is accurate regarding a 50-year-old male who was diagnosed with a submandibular gland tumor, underwent tumor removal, and subsequently experienced damage to the lingual nerve?

1. The taste sensation of the posterior one-third of the tongue is lost
2. The taste sensation of the anterior two-thirds of the tongue is lost
3. A general sensation of the posterior one-third of the tongue is lost
4. A general sensation of the anterior two-thirds of the tongue is lost

 Answer: 4) A general sensation of the anterior two-thirds of the tongue is lost

Also read: FMGE Previous Year Question Papers

Q21. Surfactant is secreted by which of the following?

1. Type I pneumocyte
2. Type Il pneumocyte
3. Sertoli cell
4. Leydig cell

 Answer: 2) Type Il pneumocyte

Q22. Which of the following is the best stimulus for the release of vasopressin

1. Hypotonicity of extracellular fluid
2. Hypertension
3. Hypotension
4. Hypo-osmolarity of extracellular fluid

 Answer: 3) Hypotension

Also read: Most IMP Biochemistry PYQs for FMGE

Q23. What is the cause of dicrotic notch?

1. Passive filling of blood in ventricles
2. Rapid ejection phase
3. Closure of semilunar valves
4. Isovolumic contraction

Answer: 3 - Closure of semilunar valves

Also read: FMGE Previous Year Questions for PSM

Q24. Which of the following statements accurately describes Isovolumic relaxation?

1. AV valves are closed
2. Corresponds to QT interval
3. 'C' wave of JVP
4. Semilunar valves open

Answer  A - Potassium ions

Q25. Adequate O₂ oxygen delivery at cellular level occurs in which type of hypoxia?

1. Hypoxic
2. Anaemic
3. Stagnant
4. Histotoxic

Answer : 4 - Histotoxic

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