May 19, 2025
Epidemiology of Congenital CMV
Clinical Picture in Congenital CMV
Diagnosis of Congenital CMV
Treatment
Diagnosis of Congenital Rubella
Treatment of Congenital Rubella
Diagnosis of Congenital Toxoplasmosis
Treatment and Prevention
Diagnosis
Treatment
Diagnosis
Treatment
Diagnosis
Treatment
Infections may be mild/asymptomatic in pregnant females but can have disastrous results in fetuses/neonates. No role of routine TORCH serology testing since IgG antibodies in the mother may show past infections and can be passively transferred. A pathogen-specific fetal IgM indicates infection but has variable sensitivity and specificity (higher specificity, moderate sensitivity). A negative fetal IgM does not rule out congenital infection. Paired IgG titres in mother and baby are useful in congenital syphilis.
Agent: Cytomegalovirus (CMV)- A dsDNA, an enveloped virus that belongs to the Herpes family. Highly-species specific and affected cells appear large, with abundant cytoplasm and both intranuclear and cytoplasmic inclusions. CMV is a virus that is present in all body secretions and is highly transmissible.
Maternal infection with CMV during pregnancy
Also read: Pediatric Neonatology High Yield One Liners
90% of patients are asymptomatic and 10% of patients are symptomatic(<5%-severe multiorgan dysfunction). The most common symptoms are petechiae and Purpura rash (57-79%). Other symptoms:
Also read: NEET SS Pediatric Neonatology Important Topics
Also read: Intraventricular Hemorrhage In Neonates
Causative agent: Toxoplasma gondii. An obligate intracellular protozoan parasite. Cats are the definitive host and man is an intermediate host. Most cases of congenital infection occur via transplacental spread. Mother gets primary infection in pregnancy via infected cysts.
Also read: Neonatal Hypocalcemia
Also read: Fetal Assessment: Key Evaluations & Prenatal Diagnosis
Management is primarily supportive
Also read: Food Allergy in children
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